Heterogeneity of insulin-dependent diabetes-new evidence.
Heterogeneity of insulin-dependent diabetes-new evidence.
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胰岛素依赖性糖尿病的异质性——新证据。
DOI：
10.1111/j.1399-0004.1982.tb00756.x
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发表时间：
1982
影响因子：
3.5
通讯作者：
Barbosa,J
中科院分区：
文献类型：
--
作者：
Dunsworth,TS;Rich,SS;Morton,NE;Barbosa,J
我们对182个至少有一个胰岛素依赖型糖尿病先证者的家庭进行了复杂的分离和连锁分析。所有的家庭分型为B组织相容性（HLA）抗原和118 DR。隐性模型拟合数据最好，与HLA DR和易感性因子之间的重组的最大似然估计为0.019。提示存在实质性异质性，先证者具有两个高风险DR等位基因的家系的重组估计值最小。结果与强的、紧密HLA连锁的易感因素和其他非HLA连锁遗传因素的证据相一致。
We have performed complex segregation and linkage analysis in 182 families with at least one insulin‐dependent diabetic proband. All families were typed for B histocompatibility (HLA) antigens and 118 for DR. The recessive model fit the data best, with maximum likelihood estimates of recombination between HLA DR and the susceptibility factor of 0.019. Substantial heterogeneity was suggested, with smallest estimated recombination for pedigrees whose probands have two high‐risk DR alleles. The results are compatible with a strong, tightly HLA‐linked susceptibility factor and evidence for additional non‐HLA linked genetic factor(s).