EXPRESSION OF THE NEUROGLANDULAR ANTIGEN AND ANALOGS IN MELANOMA - CD9 EXPRESSION APPEARS INVERSELY RELATED TO METASTATIC POTENTIAL OF MELANOMA
EXPRESSION OF THE NEUROGLANDULAR ANTIGEN AND ANALOGS IN MELANOMA - CD9 EXPRESSION APPEARS INVERSELY RELATED TO METASTATIC POTENTIAL OF MELANOMA
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DOI：
10.1002/ijc.2910540107
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发表时间：
1993-04-22
影响因子：
6.4
通讯作者：
HERSEY, P
中科院分区：
文献类型：
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作者：
SI, ZY;HERSEY, P
使用免疫组织学方法来检查黑色素瘤的转移潜力与神经腺抗原（CD63）和该分子家族的其他成员、CD53、CD37、CD9和抗增殖抗体（TAPA-I）的靶标以及MHC-I类和II类抗原的表达之间的关系。用于确定转移潜力的标准是它们与原发性黑色素瘤厚度的关系，以及原发性黑色素瘤垂直和径向生长阶段之间以及原发性和转移性黑色素瘤之间表达的差异。基底细胞癌（BCC）和鳞状细胞癌（SCC）的研究也被纳入作为低转移性恶性皮肤癌的对照。发现CD9和MHC-I类抗原的表达与原发肿瘤的厚度呈负相关，并且CD9主要在原发肿瘤而不是转移肿瘤上表达。 CD9表达与黑色素瘤上的MHC-I类表达相关，并且两者均在低转移潜能的BCC和SCC上表达，但在复合痣上不表达。 CD63和TAPA-I在痣上表达，但在SCC和BCC上不表达。 Leu 13 是淋巴瘤中与 TAPA-I 相关的分子，被发现在 34 个原发性黑色素瘤中的 5 个和 21 个转移性黑色素瘤中的 S 切片中表达。黑色素瘤中未检测到 CD53 和 CD37。我们的结果表明，神经腺抗原的几个成员在黑色素瘤中表达，并且原发性黑色素瘤上 CD9 的低表达可能对于转移的可能性具有预后意义。
Immunohistological methods were used to examine the relation between the metastatic potential of melanoma and expression of the neuroglandular antigen (CD63) and other members of this family of molecules, CD53, CD37, CD9 and the target of an anti-proliferative antibody (TAPA-I), as well as MHC-class-I and -II antigens. The criteria used to establish metastatic potential were their relation to thickness of the primary melanoma, and differences in expression between vertical and radial growth phases of primary melanoma and between primary and metastatic melanoma. Studies on basal-cell carcinoma (BCC) and squamous-cell carcinoma (SCC) were also included as controls for malignant skin cancers with low metastatic potential. Expression of CD9 and MHC-class-I antigen was found to be inversely related to thickness of the primary tumor, and CD9 was expressed predominantly on primary rather than on metastatic tumors. CD9 expression correlated with MHC-class-I expression on melanoma, and both were expressed on BCCs and SCCs having low metastatic potential, but not on compound nevi. CD63 and TAPA-I were expressed on nevi but not on SCC and BCC. Leu 13 is a molecule associated with TAPA-I in lymphomas, and was found to be expressed in sections from 5 out of 34 primary and S out of 21 metastatic melanoma. CD53 and CD37 were not detected on melanoma. Our results indicate that several members of the neuroglandular antigen are expressed in melanoma and that low expression of CD9 on primary melanomas might have prognostic significance with respect to the potential for metastasis.