The contrasting roles of primary cilia and cytonemes in Hh signaling.
The contrasting roles of primary cilia and cytonemes in Hh signaling.
复制标题
初级纤毛和细胞因子在 Hh 信号传导中的对比作用。
DOI：
10.1016/j.ydbio.2014.07.015
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发表时间：
2014
影响因子：
2.7
通讯作者：
Kornberg,ThomasB
中科院分区：
文献类型：
--
作者：
Kornberg,ThomasB
Hedgehog (Hh) is a paracrine signaling protein with major roles in development and disease. In vertebrates and invertebrates, Hh signal transduction is carried out almost entirely by evolutionarily conserved components, and in both, intercellular movement of Hh is mediated by cytonemes – specialized filopodia that serve as bridges that bring distant cells into contact. A significant difference is the role of the primary cilium, a slender, tubulin-based protuberance of many vertebrate cells. Although the primary cilium is essential for Hh signaling in cells that have one, most Drosophila cells lack a primary cilium. This perspective addresses the roles of primary cilia and cytonemes, and proposes that for Hh signaling, the role of primary cilia is to provide a specialized hydrophobic environment that hosts lipid-modified Hh and other components of Hh signal transduction after Hh has traveled from elsewhere in the cell. Implicit in this model is the idea that initial binding and uptake of Hh is independent of and segregated from the processes of signal transduction and activation.
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影响因子：
11.8
作者：
Izzi, Luisa;Levesque, Martin;Morin, Steves;Laniel, Dominique;Wilkes, Brian C.;Mille, Frederic;Krauss, Robert S.;McMahon, Andrew P.;Allen, Benjamin L.;Charron, Frederic
通讯作者：
Charron, Frederic
形态原分散的直接传递机制
影响因子：
7.3
作者：
Sougata Roy;T. Kornberg
通讯作者：
T. Kornberg
DOI：
10.1126/science.1244624
发表时间：
2014-02-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Roy S;Huang H;Liu S;Kornberg TB
通讯作者：
Kornberg TB
影响因子：
5.8
作者：
Ogden, SK;Ascano, M;Robbins, DJ
通讯作者：
Robbins, DJ
影响因子：
9.2
作者：
Farzan, Shohreh F.;Ascano, Manuel, Jr.;Ogden, Stacey K.;Sanial, Matthieu;Brigui, Amira;Plessis, Anne;Robbins, David J.
通讯作者：
Robbins, David J.