Divergent brain network connectivity in amyotrophic lateral sclerosis
Divergent brain network connectivity in amyotrophic lateral sclerosis
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DOI：
10.1016/j.neurobiolaging.2012.04.015
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发表时间：
2013-02-01
影响因子：
4.2
通讯作者：
Filippi, Massimo
中科院分区：
文献类型：
--
作者：
Agosta, Federica;Canu, Elisa;Filippi, Massimo
采用静息态（RS）功能磁共振成像和独立成分分析，对20例肌萎缩侧索硬化（ALS）非痴呆患者的认知和行为相关脑网络的完整性进行了研究。对16例患者进行神经心理学评估，评估RS功能连接与执行功能之间的关系。与对照组相比，ALS患者在默认模式网络中右眶额皮质的连接性降低，左楔前叶的连接性增强;左额下皮质的连接性降低，右额顶网络中右角回的连接性增加;左额顶网络中顶叶皮质的连接性增加。增强的顶叶连接与患者的临床和认知缺陷有关。在ALS中，即使没有明显的痴呆，与认知相关的大规模功能性大脑网络也会发生改变。顶叶连接的增加可能在结构性额颞叶损伤的情况下试图维持认知效率方面发挥作用。(C)2013 Elsevier Inc. All rights reserved.
Using resting state (RS) functional magnetic resonance imaging and independent component analysis, the integrity of brain networks related to cognition and behavior was investigated in 20 nondemented patients with amyotrophic lateral sclerosis (ALS). The association between RS functional connectivity and executive functions was assessed in 16 patients with neuropsychological assessment. ALS patients compared with control subjects showed a decreased connectivity of the right orbitofrontal cortex, and an enhanced connectivity of the left precuneus in the default mode network; a decreased connectivity of the left inferior frontal cortex, and an increased connectivity of the right angular gyrus in the right frontoparietal network; and an increased connectivity of the parietal cortex in the left frontoparietal network. The enhanced parietal connectivity was associated with the clinical and cognitive deficits of the patients. In ALS, an alteration of large-scale functional brain networks associated with cognition does occur, even in the absence of overt dementia. The increased parietal connectivity may have a role in an attempt to maintain cognitive efficiency in the presence of structural frontotemporal injury. (C) 2013 Elsevier Inc. All rights reserved.