Analysis of coagulation proteins as acute-phase reactants in horses with colic.
Analysis of coagulation proteins as acute-phase reactants in horses with colic.
复制标题
分析作为绞痛马急性期反应物的凝血蛋白。
DOI：
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发表时间：
1998
影响因子：
1
通讯作者：
K. W. Prasse
中科院分区：
文献类型：
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作者：
Michael J. Topper;K. W. Prasse
目标
在选定的绞痛和止血异常马群体中，测定凝血因子VIII：凝血剂（F.VIII：C）和C1-酯酶抑制剂（C1-INH）、止血相关急性期反应物蛋白和凝血因子VII（F.VII）、IX（F.IX）和X（F.X）、与急性期反应无关的止血蛋白，并假定其具有急性期变化。比较绞痛马的这些值和其他常规止血试验结果与健康马群体的值。将已知马急性期反应物F.VIII：C和纤维蛋白原的值与其他止血试验的值相关联。识别止血相关的急性期反应物蛋白，并深入了解急性期反应对患有绞痛综合征的马的止血异常的影响。
样本群体
54份血浆样本来自患有可归因于炎症性（n = 39）或绞窄性（n = 15）肠道疾病的绞痛的马。
程序
评价血浆样品的F.VII、F.VIII：C、F.IX、F.X、C1-INH、抗凝血酶III、蛋白C、纤溶酶原和α 2-抗纤溶酶（α 2AP）的活性;纤维蛋白原浓度;以及凝血酶原（PT）和活化部分凝血活酶（APTT）时间。
结果
马绞痛有显着较高的纤维蛋白原浓度，更大的α 2AP和蛋白C的活动，以及较长的PT和APTT比健康的马。马绞痛也有显着降低平均F.VII活性比健康的马。纤维蛋白原浓度与F.VIII：C、C1-INH和α 2AP值之间以及F.VIII：C活性与纤维蛋白原、C1-INH、α 2AP和纤溶酶原值之间存在显著正相关。
结论
急性期反应有助于观察到的变化，在马与绞痛归因于炎症和绞窄性肠道疾病的凝血蛋白。这些数据表明，纤溶酶原，α 2AP，和C1-INH，应被视为马急性时相蛋白。
OBJECTIVES
To measure coagulation factor VIII:coagulant (F.VIII:C) and C1-esterase inhibitor (C1-INH), hemostasis-associated acute-phase reactant proteins and coagulation factors VII (F.VII), IX (F.IX), and X (F.X), hemostasis proteins not associated with an acute-phase response, in a select population of horses with colic and hemostasis abnormalities, and presumed to have acute-phase changes. To compare these values and other routine hemostasis test results in the horses with colic with values for a population of healthy horses. To correlate the values of known equine acute-phase reactants, F.VIII:C and fibrinogen, to those of other tests of hemostasis. To identify hemostasis-associated acute-phase reactant proteins and gain insights into the effects the acute-phase response has on hemostatic abnormalities in horses with colic syndrome.
SAMPLE POPULATION
54 plasma samples from horses with colic attributable to inflammatory (n = 39) or strangulating (n = 15) intestinal disorders.
PROCEDURE
Plasma samples were evaluated for activities of F.VII, F.VIII:C, F.IX, F.X, C1-INH, antithrombin III, protein C, plasminogen, and alpha 2-antiplasmin (alpha 2AP); fibrinogen concentration; and prothrombin (PT) and activated partial thromboplastin (APTT) times.
RESULTS
Horses with colic had significantly higher fibrinogen concentration, greater alpha 2AP and protein C activities, and longer PT and APTT than did healthy horses. Horses with colic also had significantly lower mean F.VII activity than did healthy horses. Significant positive correlations between fibrinogen concentration and F.VIII:C, C1-INH, and alpha 2AP values, and between F.VIII:C activity and fibrinogen, C1-INH, alpha 2AP, and plasminogen values were identified.
CONCLUSIONS
An acute-phase response contributes to changes observed in coagulation proteins in horses with colic attributable to inflammatory and strangulating intestinal disorders. The data suggest that plasminogen, alpha 2AP, and C1-INH, should be considered equine acute-phase proteins.