TRANSFER OF ANTI-ROTAVIRAL ANTIBODIES FROM MOTHERS TO THEIR INFANTS
TRANSFER OF ANTI-ROTAVIRAL ANTIBODIES FROM MOTHERS TO THEIR INFANTS
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DOI：
10.1128/jcm.12.3.320-325.1980
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发表时间：
1980-01-01
影响因子：
9.4
通讯作者：
HOLMES, IH
中科院分区：
文献类型：
--
作者：
MCLEAN, B;HOLMES, IH
Levels of rotavirus-specific IgG, IgA, IgM and secretory immunoglobulin in maternal and cord serum, colostrum and milk, and infants'' stools were measured by enzyme-linked immunosorbent assay in 92 mothers and their infants. Although antirotaviral IgG, IgA and secretory immunoglobulin were present in most maternal sera, only IgG crossed the placenta. All samples of colostrum and milk tested contained antirotaviral secretory immunoglobulin and IgA except those of 2 women in whom IgA deficiency was subsequently described. Specific IgM and IgG were also detected in many colostral samples. Antirotaviral IgA was detected in many colostral samples. Antirotaviral IgA was detected in stools of breast-fed but not bottle-fed neonates. Apparently the human infant receives rotaviral antibodies both transplacentally and via maternal colostrum and milk.
