High-resolution longitudinal MRI of the transition to heart failure
High-resolution longitudinal MRI of the transition to heart failure
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DOI：
10.1002/mrm.21182
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发表时间：
2007-04-01
影响因子：
3.3
通讯作者：
Frank, Lawrence R.
中科院分区：
文献类型：
--
作者：
Costandi, Peter N.;McCulloch, Andrew D.;Frank, Lawrence R.
心力衰竭(HF)的发展是一个进化的过程，随着时间的推移，结构和功能都会发生变化。虽然心脏病理的生理状态已经有了很好的特征，但对从正常状态到不适应状态的转变知之甚少。磁共振成像(MRI)是一种非侵入性技术，有助于纵向实验跟踪心脏结构和生理疾病随时间的进展。心脏疾病的转基因小鼠模型，如本研究中使用的肌肉LIM蛋白缺陷株，提供了可重复的表型群体，很容易用于系列研究。在这项纵向研究中，高空间和时间分辨率的时间序列MR图像显示了一个突然而短暂的主要解剖重建阶段，在此期间，脑室扩张，室壁变薄。磁共振成像能够获得空间和时间分辨率的图像，从而能够三维估计空洞体积和壁质量随时间的变化。结论是，使用高时间分辨率的成像方案，MRI具有足够的空间和时间成像分辨率，以允许检测和量化单个小鼠心脏在走向衰竭的过程中快速发生的过渡期。
The development of heart failure (HF) is an evolving process that entails both structural and functional changes through time. While the physiological state of cardiac pathologies has been well characterized, less is known about the transition from a normal to a maladaptive state. Magnetic resonance imaging (MRI) is a noninvasive technique that facilitates longitudinal experiments to follow the progression of cardiac structural and physiological disorders over time. Transgenic murine models of cardiac disease, such as the muscle LIM protein-deficient strain used in this study, offer populations of a reproducible phenotype that readily lend themselves to serial studies. In this longitudinal study, high spatial and temporal resolution time-course MR images revealed an abrupt and brief phase of major anatomical restructuring during which the ventricular chamber dilated and the wall thinned. The ability of MRI to acquire spatially and temporally resolved images enabled the 3D estimation of cavity volume and wall mass changes with time. It was concluded that, using an imaging protocol of high temporal resolution, MRI has the adequate spatial and temporal imaging resolution to allow for the detection and quantification of rapidly occurring transitional phases in a single mouse heart as it progresses toward failure.