Cerebral angiogenesis: a realistic therapy for ischemic disease?
Cerebral angiogenesis: a realistic therapy for ischemic disease?
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DOI：
10.1007/978-1-4939-0320-7_2
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Greenberg DA
中科院分区：
文献类型：
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作者：
Greenberg DA
血管生成，即新毛细血管从现有血管中发芽，伴随临床和实验性卒中，尤其集中在可挽救的缺血边缘区。由于这种内源性血管生成反应与临床预后呈正相关，因此更全面地了解这些事件的潜在分子机制和时间可能有助于设计卒中后血管再生的新疗法。在这篇综述中，我们讨论了内源性保护机制，包括血管生成和血管生成，和潜在的分子机制。我们还考虑了血管生成治疗中风的可行性及其最佳时机。
Angiogenesis, the sprouting of new capillaries from existing blood vessels, accompanies clinical and experimental stroke and is focused particularly in the salvageable ischemic border zone. As this endogenous angiogenic response correlates positively with clinical prognosis, a more complete understanding of the underlying molecular mechanisms and timing of these events may help in the design of novel therapies for vascular regeneration after stroke. In this review we discuss endogenous protective mechanisms, including angiogenesis and vasculogenesis, and underlying molecular mechanisms. We also consider the feasibility of angiogenic therapy for stroke and its optimal timing.