Impact of Periodic Follow-Up Testing Among Urban American Indian Women With Impaired Fasting Glucose
Impact of Periodic Follow-Up Testing Among Urban American Indian Women With Impaired Fasting Glucose
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发表时间：
2008-06
影响因子：
5.5
通讯作者：
P. Allen;J. Thompson;C. Herman;Ayn N. Whyte;Venita K. Wolfe;C. Qualls;D. Helitzer
中科院分区：
文献类型：
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作者：
P. Allen;J. Thompson;C. Herman;Ayn N. Whyte;Venita K. Wolfe;C. Qualls;D. Helitzer
空腹血糖受损（IFG）通常进展为2型糖尿病。鉴于这一疾病的严重性和普遍性，初级预防很重要。强化的生活方式咨询干预措施延缓或预防了2型糖尿病的发病，但不知道强度较小，更容易复制的努力是否也有效。方法在一项旨在降低2型糖尿病风险的生活方式干预研究中，从城市社区招募了200名年龄在18至40岁的无糖尿病的美国印第安妇女，不考虑体重或IFG，并根据空腹血糖（FBG）随机分为干预组和对照组。报告饮食和体力活动行为，并在基线和18个月的定期随访时进行临床代谢、健身和身体成分测量。美国印第安人调解人在前6个月使用小组讨论的形式，提供了一个文化影响的健康饮食，体育活动，社会支持和目标设定的教育干预。我们分析了一个子集的年轻美国印第安妇女IFG在基线（n = 42），从干预组和对照组。结果在IFG患者中，平均FBG从基线到随访时显著下降（P <0.001），在完成18个月随访的30名女性中，62.0%的女性转为正常（<5.6 mmol/L或<100 mg/dL），无论是否参加团体教育课程。其他改善的代谢值包括平均空腹血总胆固醇和低密度脂蛋白胆固醇水平的显着降低。这些妇女报告说，总能量、饱和脂肪、总脂肪、总糖、含糖饮料、饮食中甜食的比例和看电视的时间总体平均摄入量显著下降。结论本研究中IFG志愿者从了解其FBG值和报告其饮食模式中受益;他们改变了饮食，改善了FBG和血脂。如果在更大的样本中得到证实，这些结果支持定期饮食和身体成分评估，以及IFG女性的血糖监测。
Introduction Impaired fasting glucose (IFG) often progresses to type 2 diabetes. Given the severity and prevalence of this disease, primary prevention is important. Intensive lifestyle counseling interventions have delayed or prevented the onset of type 2 diabetes, but it is not known whether less intensive, more easily replicable efforts can also be effective. Methods In a lifestyle intervention study designed to reduce risks for type 2 diabetes, 200 American Indian women without diabetes, aged 18 to 40 years, were recruited from an urban community without regard to weight or IFG and block-randomized into intervention and control groups on the basis of fasting blood glucose (FBG). Dietary and physical activity behaviors were reported, and clinical metabolic, fitness, and body composition measures were taken at baseline and at periodic follow-up through 18 months. American Indian facilitators used a group-discussion format during the first 6 months to deliver a culturally influenced educational intervention on healthy eating, physical activity, social support, and goal setting. We analyzed a subset of young American Indian women with IFG at baseline (n = 42), selected from both the intervention and control groups. Results Among the women with IFG, mean FBG significantly decreased from baseline to follow-up (P < .001) and converted to normal (<5.6 mmol/L or <100 mg/dL) in 62.0% of the 30 women who completed the 18-month follow-up, irrespective of participation in the group educational sessions. Other improved metabolic values included significant decreases in mean fasting blood total cholesterol and low-density lipoprotein cholesterol levels. The women reported significant overall mean decreases in intake of total energy, saturated fat, total fat, total sugar, sweetened beverages, proportion of sweet foods in the diet, and hours of TV watching. Conclusion Volunteers with IFG in this study benefited from learning their FBG values and reporting their dietary patterns; they made dietary changes and improved their FBG and lipid profiles. If confirmed in larger samples, these results support periodic dietary and body composition assessment, as well as glucose monitoring among women with IFG.