Rapid measurement of actinides in urine by mass and alpha spectrometric methods
Rapid measurement of actinides in urine by mass and alpha spectrometric methods
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通过质谱和 α 光谱方法快速测量尿液中的锕系元素
DOI：
10.1093/rpd/ncad005
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发表时间：
2023
影响因子：
1
通讯作者：
Guosheng Yang; Jian Zheng; Munehiko Kowatari; Eunjoo Kim; Osamu Kurihara
中科院分区：
文献类型：
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作者：
Gohara S;Shinohara K;Yoshida R;Kariya R;Tazawa H;Hashimoto M;Inoue J;Kubo R;Nakashima H;Arita H;Kawaguchi S;Yamana K;Nagao Y;Iwamoto A;Sakata J;Matsuoka Y;Takeshita H;Hirayama M;Kawahara K;Nagata M;Hirosue A;Kuwahara Y;Fukumoto M;Ok;Guosheng Yang; Jian Zheng; Munehiko Kowatari; Eunjoo Kim; Osamu Kurihara
为了提供及时的信息以促进紧急放射治疗的决策，我们开发了简单快速的质谱和 α 光谱方法，用于尿液生物测定，以确定超痕量锕系元素同位素。对于质谱法，经过有机物分解、LaF3/CaF2共沉淀并使用2ml AG MP-1M阴离子交换树脂进行色谱纯化后，通过电感耦合等离子体质谱法测定20ml尿样中的U和Pu同位素。在 α 光谱法中，经过有机物分解、氢氧化铁共沉淀和使用 2 ml TEVA 和 2 ml DGA 树脂柱进行色谱纯化后，通过 α 光谱法测量 500 ml 尿样中的 Pu、U 和 Am/Cm 同位素。然后将这些 α 和质谱方法用于参加法国放射毒理学分析质量控制促进协会 (PROCORAD) 组织的 2020 年比对，以进行方法验证。
To provide timely information for prompting decision-making in emergency radiation therapy, we developed simple and rapid mass and alpha spectrometric methods for urinary bioassays to determine ultra-trace actinide isotopes. For the mass spectrometric method, after organic matter decomposition, LaF3/CaF2co-precipitation and chromatographic purification using 2 ml of AG MP-1 M anion exchange resin, U and Pu isotopes were measured in a 20-ml urine sample by inductively coupled plasma-mass spectrometry. In the alpha spectrometric method, after organic matter decomposition, iron hydroxide co-precipitation and chromatographic purification using 2 ml of TEVA and 2 ml of DGA resin cartridges, Pu, U and Am/Cm isotopes were measured in a 500-ml urine sample by alpha spectrometry. These alpha and mass spectrometric methods were then applied for participation in the 2020 intercomparison organized by the Association for the PROmotion of Quality COntrol in RADiotoxicological Analysis (PROCORAD), France, for method validations.