Indole alkaloids and other constituents of Rauwolfia serpentina
Indole alkaloids and other constituents of Rauwolfia serpentina
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DOI：
10.1021/np058007n
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发表时间：
2005-06-01
影响因子：
5.1
通讯作者：
Tanahashi, T
中科院分区：
文献类型：
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作者：
Itoh, A;Kumashiro, T;Tanahashi, T
从蛇毛狼（Rauwolfia serpentina）干根中分离得到5个新的吲哚类生物碱，n -b-甲基异ajmaline(2)， 3-羟基山莨菪碱(3)，育亨宾酸(4)，异奥亨宾酸(5)，一个新的环烯醚萜类糖苷，7- epiloanin(6)和一个新的蔗糖衍生物，6'- o -（3,4,5-三甲氧基苯甲酰）glomeratose a(7)，以及20个已知化合物。用光谱学和化学方法确定了新化合物的结构。测定了所选生物碱对拓扑异构酶I和拓扑异构酶II的抑制活性及其对人早幼粒细胞白血病（HL-60）细胞株的细胞毒性。
From the dried roots of Rauwolfia serpentina were isolated five new indole alkaloids, N-b-methylajmaline (1), N-b-methylisoajmaline (2), 3-hydroxysarpagine (3), yohimbinic acid (4), isorauhimbinic acid (5), a new iridoid glucoside, 7-epiloganin (6), and a new sucrose derivative, 6'-O-(3,4,5-trimethoxybenzoyl)glomeratose A (7), together with 20 known compounds. The structures of the new compounds were determined by spectroscopic and chemical means. The inhibitory activities of the selected alkaloids on topoisomerase I and II and their cytotoxicity against the human promyelocytic leukemia (HL-60) cell lines were assessed.