Amino-terminal amino acid sequence and carboxyl-terminal analysis of Rauscher murine leukemia virus glycoproteins.
Amino-terminal amino acid sequence and carboxyl-terminal analysis of Rauscher murine leukemia virus glycoproteins.
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Rauscher 鼠白血病病毒糖蛋白的氨基末端氨基酸序列和羧基末端分析。
DOI：
10.1016/0042-6822(78)90437-3
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发表时间：
1978
期刊：
影响因子：
3.7
通讯作者：
S. Oroszlan
中科院分区：
文献类型：
--
作者：
L. Henderson;T. Copeland;G. Smythers;H. Marquardt;S. Oroszlan
小鼠白血病病毒的两个糖蛋白gp70和gp45具有相同的nh2末端氨基酸序列：Ala-Ala-Pro-Gly-Ser-Pro-His-Gln-Val-Tyr-X-Ile-Thr-X-Glu-Val-（X-未知）。gp70的cooh末端氨基酸为酪氨酸，gp45的cooh末端氨基酸为亮氨酸。计算机分析的氨基酸组成数据表明，gp45的蛋白质片段比gp70的小。这些结果与gp45是由gp70通过蛋白水解裂解而来的说法一致。
The two glycoproteins of Rauscher murine leukemia virus, gp70 and gp45, were found to have the following identical NH2-terminal amino acid sequences: Ala-Ala-Pro-Gly-Ser-Pro-His-Gln-Val-Tyr-X-Ile-Thr-X-Glu-Val-(X- unidentified). The COOH-terminal amino acid of gp70 is tyrosine and that of gp45 is leucine. Computer-analyzed amino acid compositional data indicated that the protein moiety of gp45 is smaller than that of gp70. These results are compatible with the suggestion that gp45 is derived from gp70 by proteolytic cleavage.