Infections and Risk of Celiac Disease in Childhood: A Prospective Nationwide Cohort Study
Infections and Risk of Celiac Disease in Childhood: A Prospective Nationwide Cohort Study
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DOI：
10.1038/ajg.2015.287
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发表时间：
2015-10-01
影响因子：
9.8
通讯作者：
Stordal, Ketil
中科院分区：
文献类型：
--
作者：
Marild, Karl;Kahrs, Christian R.;Stordal, Ketil
目的：关于生命早期感染和晚期乳糜泻（CD）风险的研究不一致，但大多限于回顾性设计、住院数据或统计学把握度不足。我们的目的是测试是否与早期生命感染的风险增加以后CD使用前瞻性人群为基础的data.METHODS：这项研究的基础上，挪威母亲和儿童队列研究，包括前瞻性的，重复评估的父母报告的传染病数据长达18个月的年龄为72,921名儿童出生于2000年和2009年之间。通过父母问卷调查和挪威患者登记确定CD。Logistic回归用于估计儿童年龄和性别调整后的优势比（aOR）。结果：在中位数为8.5年的随访期间（范围，4.5-14.5），581名儿童（0.8%）被诊断为CD。在18个月内有≥ 10次感染（≥第四四个四分位数）的儿童，与有≥ 10次感染的儿童相比，
OBJECTIVES: Studies on early life infections and risk of later celiac disease (CD) are inconsistent but have mostly been limited to retrospective designs, inpatient data, or insufficient statistical power. We aimed to test whether early life infections are associated with increased risk of later CD using prospective population-based data.METHODS: This study, based on the Norwegian Mother and Child Cohort Study, includes prospective, repeated assessments of parent-reported infectious disease data up to 18 months of age for 72,921 children born between 2000 and 2009. CD was identified through parental questionnaires and the Norwegian Patient Registry. Logistic regression was used to estimate odds ratios adjusted for child's age and sex (aOR).RESULTS: During a median follow-up period of 8.5 years (range, 4.5-14.5), 581 children (0.8%) were diagnosed with CD. Children with >= 10 infections (>= fourth quartile) up to age 18 months had a significantly higher risk of later CD, as compared with children with