Synthesis of 1,2,3-benzotriazin-4-one derivatives containing spirocyclic indoline-2-one moieties and their nematicidal evaluation
Synthesis of 1,2,3-benzotriazin-4-one derivatives containing spirocyclic indoline-2-one moieties and their nematicidal evaluation
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DOI：
10.1016/j.cclet.2015.10.024
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发表时间：
2015-12
影响因子：
9.1
通讯作者：
Gaolei Wang;Xi Chen;Yaning Chang;Dan Du;Zhong Li;Xiaoyong Xu
中科院分区：
文献类型：
--
作者：
Gaolei Wang;Xi Chen;Yaning Chang;Dan Du;Zhong Li;Xiaoyong Xu
为了发现新的具有适当毒性的杀线虫剂，合成了一系列新的1，2，3-苯并三嗪-4-酮衍生物并进行了生物活性评价。生物活性测定结果表明，大部分化合物在10.0mg/L的浓度下对南方根结线虫有较好的防治效果。其中化合物6 k和6p在此浓度下对线虫的抑制率均为100%，表明它们可作为有前途的杀线虫剂的先导化合物。
To discover new chemotypes of nematicides with proper toxicological profiles, a series of novel 1,2,3-benzotriazin-4-one derivatives were synthesized and further bioevaluated. The bioassay results showed that most of the synthesized compounds were endowed with moderate to good control efficacy againstMeloidogyne incognitaat 10.0 mg/Lin vivo. Among them, compounds6kand6pdisplayed 100% inhibitory activities at this concentration, which implied that they could be used as lead compounds for promising nematicides.