Active Surface Flows Accelerate the Coarsening of Lipid Membrane Domains
Active Surface Flows Accelerate the Coarsening of Lipid Membrane Domains
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活性表面流加速脂质膜域的粗化
DOI：
10.1103/physrevlett.131.128402
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发表时间：
2023
影响因子：
8.6
通讯作者：
Takatori, Sho C.
中科院分区：
文献类型：
--
作者：
Arnold, Daniel P.;Gubbala, Aakanksha;Takatori, Sho C.
多组分脂质膜的相分离的特征在于圆形膜域的成核和粗化，所述圆形膜域随时间缓慢生长，遵循聚结和奥斯特瓦尔德熟化的经典理论。在这封信中，我们研究了相分离脂膜的粗化动力学进行非平衡力和电机驱动的滑动肌动蛋白丝传输的流量。我们的实验观察到，活动引起的表面流触发快速粗化的非圆形膜域的增长，aacceleration的增长指数相比，被动聚结和奥斯特瓦尔德熟化。我们分析了这些结果，通过发展分析理论的基础上的Smoluchowski凝聚模型和相场模型来预测域的增长中存在的活跃的流量。我们的信表明，活性物质力可用于控制被逐出平衡的膜结构域的生长和形态。
Phase separation of multicomponent lipid membranes is characterized by the nucleation and coarsening of circular membrane domains that grow slowly in time as, following classical theories of coalescence and Ostwald ripening. In this Letter, we study the coarsening kinetics of phase-separating lipid membranes subjected to nonequilibrium forces and flows transmitted by motor-driven gliding actin filaments. We experimentally observe that the activity-induced surface flows trigger rapid coarsening of noncircular membrane domains that grow as, aacceleration in the growth exponent compared to passive coalescence and Ostwald ripening. We analyze these results by developing analytical theories based on the Smoluchowski coagulation model and the phase field model to predict the domain growth in the presence of active flows. Our Letter demonstrates that active matter forces may be used to control the growth and morphology of membrane domains driven out of equilibrium.