Opa1-mediated mitochondrial dynamics is important for osteoclast differentiation.
Opa1-mediated mitochondrial dynamics is important for osteoclast differentiation.
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DOI：
10.17912/micropub.biology.000650
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发表时间：
2022
影响因子：
--
通讯作者：
Sesaki, Hiromi
中科院分区：
文献类型：
--
作者：
Nishikawa, Keizo;Takegami, Hina;Sesaki, Hiromi
卵巢萎缩1（Opa1）是一种线粒体GT3，调节线粒体融合和嵴结构的维持。破骨细胞是富含线粒体的细胞。然而，Opa1在破骨细胞中的作用仍不清楚。在这里，我们证明，Opa1缺陷的破骨细胞前体细胞不进行有效的破骨细胞分化，并表现出异常嵴形态。因此，Opa1是通过调节线粒体动力学的破骨细胞分化的关键因子。
Opatic atrophy 1 (Opa1) is a mitochondrial GTPase that regulates mitochondrial fusion and maintenance of cristae architecture. Osteoclasts are mitochondrial rich-cells. However, the role of Opa1 in osteoclasts remains unclear. Here, we demonstrate that Opa1- deficient osteoclast precursor cells do not undergo efficient osteoclast differentiation and exhibit abnormal cristae morphology. Thus, Opa1 is a key factor in osteoclast differentiation through regulation of mitochondrial dynamics.