INJECTION OF FREE-RADICAL GENERATORS CAUSES PREMATURE ONSET OF TISSUE-DAMAGE IN MALARIA-INFECTED MICE
INJECTION OF FREE-RADICAL GENERATORS CAUSES PREMATURE ONSET OF TISSUE-DAMAGE IN MALARIA-INFECTED MICE
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DOI：
10.1002/path.1711480406
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发表时间：
1986-04-01
影响因子：
7.3
通讯作者：
COWDEN, WB
中科院分区：
文献类型：
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作者：
CLARK, IA;MACKIE, EJ;COWDEN, WB
在寄生虫血症达到70- 80%并且小鼠显示出疾病迹象之前，通常不会在感染了疟原虫的小鼠中发生类疟原虫和肝损伤。我们在这里报告，这些变化可以诱导小鼠的健康外观和较低的寄生虫血症，通过注射divicine或叔丁基过氧化氢，两个发电机的自由氧自由基。相同或更大剂量的这些自由基发生剂在正常小鼠中不会引起这种组织损伤。吞噬性白细胞在感染P. vinckei的小鼠中被激活，并且这些细胞分泌有毒的氧代谢物被认为是该过程的一部分。这些自由基和那些从divicine和叔丁基过氧化氢产生的加和效应可以解释寄生虫小鼠对这些药剂造成的组织损伤的易感性增加。
Lymphoid and liver damage does not usually occur in Plasmodium vinckei-infected mice until parasitaemias reach 70-80 per cent and the mice are showing signs of illness. We report here that these changes can be induced in mice of healthy appearance and lower parasitaemia by injecting divicine or tertiary-butyl hydroperoxide, two generators of free oxygen radicals. The same or larger doses of these radical generators did not induce this tissue damage in normal mice. Phagocytic leukocytes are activated in P. vinckei-infected mice, and secretion by these cells of toxic oxygen metabolites has been suggested to be part of this process. Additive effects of these free radicals and those generated from divicine and t-butyl hydroperoxide could account for the increased susceptibility of parasitized mice to tissue damage by these agents.