A multistate nosocomial outbreak of Ralstonia pickettii colonization associated with an intrinsically contaminated respiratory care solution
A multistate nosocomial outbreak of Ralstonia pickettii colonization associated with an intrinsically contaminated respiratory care solution
复制标题
DOI：
10.1086/313458
复制
发表时间：
1999-11-01
影响因子：
11.8
通讯作者：
Jarvis, WR
中科院分区：
文献类型：
--
作者：
Labarca, JA;Trick, WE;Jarvis, WR
从1998年2月1日至4月30日，4家医院共报告了34例皮氏罗尔斯通氏菌定植患者，除1例外，所有患者均暴露于1家公司生产的0.9%盐水溶液（Modudose; Kendall，Mainsfield，MA），其在气管内抽吸期间使用，从先前未打开的小瓶中培养盐溶液产生R，pickettii，通过脉冲场凝胶电泳（PFGE）分析，所有可用的产品和患者分离株均具有基因型相关性。受污染的盐溶液是在与1983年类似爆发有关的同一工厂生产的，1983年和1998年的R。在1983年和1998年，使用0.2 μ m的筒式过滤器进行终末灭菌。pickettii应提醒医院工作人员注意产品污染的可能性。在这次疫情中，及时通知公共卫生机构导致迅速通知其他卫生保健提供者，这可能防止了更多的疫情。
From 1 February through 30 April 1998, 4 hospitals reported a total of 34 patients colonized with Ralstonia pickettii, All but 1 had been exposed to 0.9% saline solution manufactured by 1 company (Modudose; Kendall, Mainsfield, MA), which was used during endotracheal suctioning, Culture of saline solution from previously unopened vials yielded R, pickettii, All available product and patient isolates were genotypically related by pulsed-field gel electrophoresis (PFGE) analysis. The contaminated saline solution was manufactured at the same plant that had been associated with a similar outbreak in 1983, The 1983 and 1998 R. pickettii isolates were unrelated, as determined by PFGE, In both 1983 and 1998, a 0.2-mu m cartridge filter was used for terminal sterilization, The detection of R. pickettii should alert hospital personnel to the possibility of product contamination. In this outbreak, prompt notification of public health agencies resulted in rapid notification of other health care providers, which likely prevented additional outbreaks.