Communicating hydrocephalus associated with surgery or radiosurgery for vestibular schwannoma
Communicating hydrocephalus associated with surgery or radiosurgery for vestibular schwannoma
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DOI：
10.1016/j.jocn.2009.12.004
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发表时间：
2010-07-01
影响因子：
2
通讯作者：
Kim, Jong Hyun
中科院分区：
文献类型：
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作者：
Jeon, Chul-Jin;Kong, Doo-Sik;Kim, Jong Hyun
这项队列研究的目的是确定2002年1月至2007年12月期间与前庭神经鞘瘤（VS）治疗相关的交通性脑积水（HCP）的发生率。共有291名被诊断为VS的患者接受了手术切除或伽玛刀放射外科治疗（GKS）。通过分析临床数据和磁共振成像扫描，我们回顾性地回顾并比较了两种治疗方式之间交通性HCP的发生率。在其临床过程中，291名患者中有10名出现了新的交通性HCP（3.4%），90名接受GKS治疗的患者中有9名（10%）在术后出现了交通性HCP，而仅146名单独接受手术切除的患者中有1名（0.68%）随后出现了交通性HCP（p = 0.002）。从最初接受GKS治疗到出现交通性HCP的无事件生存期中位数为22个月（范围为7 - 55个月）。GKS组中出现新的交通性HCP的3名患者需要手术干预，包括脑室腹腔分流术或内镜下第三脑室造瘘术。在GKS组中，性别或肿瘤大小与交通性HCP的发生率之间没有显著相关性（p>0.05）。我们发现VS患者治疗后交通性HCP的发生率相对较高，特别是在GKS组患者中。因此，在对接受GKS治疗VS的患者进行随访时，应考虑交通性HCP的风险。（C）2010爱思唯尔有限公司保留所有权利
The purpose of this cohort study was to determine the incidence of communicating hydrocephalus (HCP) associated with the treatment of vestibular schwannoma (VS) Between January 2002 and December 2007. a total of 291 patients diagnosed with VS underwent either surgical resection or gamma knife radiosurgery (GKS) By analyzing the clinical data and MRI scans, we retrospectively reviewed and compared the incidence of communicating HCP between the two treatment modalities During their clinical course, 10 of 291 patients developed new communicating HCP (3.4%) nine of 90 patients who were treated using GKS (10%) developed communicating HCP post-procedure, while only one of 146 patients who underwent surgical resection alone (0.68%) developed subsequent communicating HCP (p = 0.002) The median event-free survival from the initial treatment with GKS to the development of communicating HCP was 22 months (range 7-55 months) Three patients who developed new communicating HCP in the GKS group required surgical intervention, including ventriculoperitoneal shunt or endoscopic third ventriculostomy There was no significant correlation between sex or tumor size and the incidence of communicating HCP in the GKS group (p > 0.05) We found a relatively high incidence of communicating HCP after treatment in patients with VS, particularly for those patients in the GKS group Therefore, the risk of communicating HCP should be considered in the follow-up of patients who undergo GKS for treatment of VS (C) 2010 Elsevier Ltd All rights reserved