Helicobacter pylori Strains and Gastric MALT Lymphoma.
Helicobacter pylori Strains and Gastric MALT Lymphoma.
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DOI：
10.3390/toxins9040132
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发表时间：
2017-04-08
期刊：
影响因子：
4.2
通讯作者：
Lehours P
中科院分区：
文献类型：
--
作者：
Floch P;Mégraud F;Lehours P
本文总结了幽门螺杆菌与胃MALT淋巴瘤（GML）相关的主要发现。综合考虑，基于其毒力因子谱的GML菌株的毒力似乎低于与消化性溃疡或胃腺癌相关的菌株。已经在GML菌株中鉴定了特定的刘易斯抗原谱，并且可能代表逃避宿主免疫应答的替代适应性机制，从而允许浸润淋巴细胞的连续抗原刺激。
This article summarizes the main findings concerning Helicobacter pylori associated with gastric MALT lymphoma (GML). Considered together, GML strains based on their virulence factor profile appear to be less virulent than those associated with peptic ulcers or gastric adenocarcinoma. A particular Lewis antigen profile has been identified in GML strains and could represent an alternative adaptive mechanism to escape the host immune response thereby allowing continuous antigenic stimulation of infiltrating lymphocytes.