Frontal cortical functional connectivity is impacted by anaesthesia in macaques
Frontal cortical functional connectivity is impacted by anaesthesia in macaques
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DOI：
10.1101/2021.06.09.447698
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发表时间：
2021-06
期刊：
影响因子：
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通讯作者：
C. Giacometti;Audrey Dureux;Delphine Autran-Clavagnier;C. R. Wilson;J. Sallet;Manon Dirheimer;E. Procyk;F. Hadj-Bouziane;C. Amiez
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文献类型：
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作者：
C. Giacometti;Audrey Dureux;Delphine Autran-Clavagnier;C. R. Wilson;J. Sallet;Manon Dirheimer;E. Procyk;F. Hadj-Bouziane;C. Amiez
神经科学的一个关键方面是确定灵长类动物的大脑网络是否以及如何进化。迄今为止，大多数比较研究都使用了静息态功能性磁共振成像（rs-fMRI）在麻醉的非人类灵长类动物和清醒的人类。然而，麻醉强烈影响rs-fMRI信号。本研究探讨了同一组猕猴的意识状态（麻醉与清醒）对人类大脑中一个特征良好的网络（扣带-额叶外侧网络）的rs-fMRI功能连接（FC）组织的影响。在清醒的猕猴中的结果显示了与先前在人类大脑中发现的相似的FC模式。喙种子在扣带沟表现出较强的相关强度与喙相比，尾侧额叶皮质区，而尾侧种子在扣带沟表现出较强的相关强度与尾侧相比，前外侧额叶皮质区。关键的是，这种反向的喙尾功能梯度在麻醉下被废除。这项研究表明，从猕猴到人类，扣带回-额叶皮层网络的FC模式是保留的，但它的一些特性只能在清醒状态下观察到，当在不同状态下比较不同物种的FC模式时，需要特别谨慎。
A critical aspect of neuroscience is to establish whether and how brain networks evolved across primates. To date, most comparative studies have used resting-state functional Magnetic Resonance Imaging (rs-fMRI) in anaesthetized non-human primates and in awake humans. However, anaesthesia strongly affects rs-fMRI signals. The present study investigated the impact of the awareness state (anaesthesia vs. awake) within the same group of macaque monkeys on the rs-fMRI functional connectivity (FC) organization of a well characterized network in the human brain, the cingulo-frontal lateral network. Results in awake macaques revealed a similar FC pattern to that previously uncovered in the human brain. Rostral seeds in the cingulate sulcus exhibited stronger correlation strength with rostral compared to caudal lateral frontal cortical areas while caudal seeds in the cingulate sulcus displayed stronger correlation strength with caudal compared to anterior lateral frontal cortical areas. Critically, this inverse rostro-caudal functional gradient was abolished under anaesthesia. This study demonstrates that the FC pattern of cingulo-frontal cortical networks is preserved from macaque to human but some of its properties can only be observed in the awake state, warranting significant caution when comparing FC patterns across species under different states.