Adrenocortical hyperactivity in depression: effects of agitation, delusions, melancholia, and other illness variables.
Adrenocortical hyperactivity in depression: effects of agitation, delusions, melancholia, and other illness variables.
复制标题
抑郁症中的肾上腺皮质功能亢进：激越、妄想、忧郁症和其他疾病变量的影响。
DOI：
10.1016/0165-1781(88)90007-8
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发表时间：
1988
影响因子：
11.3
通讯作者：
Mann,JJ
中科院分区：
文献类型：
--
作者：
Brown,RP;Stoll,PM;Stokes,PE;Frances,A;Sweeney,J;Kocsis,JH;Mann,JJ
在试图确定的相对贡献，肾上腺皮质功能亢进的抑郁症激越，妄想，和抑郁症亚型，我们测量皮质醇水平之前和之后的地塞米松93单相抑郁症住院患者。逐步多元回归分析表明，激动预测22%的方差上午皮质醇水平后地塞米松。将抑郁症和妄想症变量添加到回归模型中，分别占同一皮质醇变量方差的27%和34%。年龄、疾病严重程度和体重减轻没有增加进一步的显著预测价值。年龄、体重减轻和疾病严重程度在与其他变量分开检查时确实会影响皮质醇水平。地塞米松抑制试验（DST）的非抑制率在非酒精性抑郁症组和任何其他酒精性抑郁症组之间存在差异。这些结果表明，为什么一些差异之间可能存在的DST在妄想性抑郁症的研究，并表明，激越值得仔细评估，在未来的研究DST的反应。
In an attempt to determine the relative contributions to adrenocortical hyperactivity in depression of agitation, delusions, and melancholic subtype, we measured cortisol levels before and after dexamethasone in 93 unipolar major depressed inpatients. Stepwise multiple regression showed that agitation predicted 22% of the variance in a.m. cortisol level after dexamethasone. Addition of the variables melancholia and delusionality to the regression model accounted for 27% and 34%, respectively, of the variance in the same cortisol variable. Age, illness severity, and weight loss added no further significant predictive value. Age, weight loss, and illness severity did affect cortisol levels when examined separately from the other variables. Rate of nonsuppression on the dexamethasone suppression test (DST) differed between the nonmelancholic major depressive group and any other group with melancholia. These results suggest why some discrepancies may exist between studies of the DST in delusional depression and indicate that agitation merits careful assessment in future studies of DST response.