GABA and GABAA receptor expression on immune cells in psoriasis: a pathophysiological role
GABA and GABAA receptor expression on immune cells in psoriasis: a pathophysiological role
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DOI：
10.1007/s00403-010-1052-5
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发表时间：
2010-09-01
影响因子：
3
通讯作者：
Nordlind, Klas
中科院分区：
文献类型：
--
作者：
Nigam, Rishi;El-Nour, Husameldin;Nordlind, Klas
牛皮癣是一种慢性炎症性疾病，其中瘙痒是常见症状。瘙痒可能与γ-氨基丁酸（GABA）系统有关。使用免疫组织化学技术研究了受累和非受累银屑病皮肤以及正常健康对照皮肤中 GABA 及其 GABA(A) 受体 (R) 的分布。使用视觉模拟量表来确定瘙痒症。受累皮肤中对 GABA 配体和 GABA(A) R 具有免疫反应性的炎症细胞增加（分别 P < 0.01）。 GABA配体染色的细胞主要是巨噬细胞和一些淋巴细胞，而GABA(A)R染色的细胞是巨噬细胞、中性粒细胞或淋巴细胞。表达GABA配体（P = 0.05）和GABA（A）R（P < 0.05）的炎症细胞与瘙痒程度呈正相关。 GABA 配体及其 GABA(A) R 可能在银屑病的发病机制以及该疾病的瘙痒中发挥作用。
Psoriasis is a chronic inflammatory disease in which pruritus is a common symptom. Pruritus may be associated with the gamma-aminobutyric acid (GABA) system. The distribution of GABA and its GABA(A) receptor (R) was studied in involved and non-involved psoriatic skin, as well as normal healthy control skin, using an immunohistochemistry technique. Pruritus was determined using a visual analog scale. Inflammatory cells immunoreactive for the GABA ligand and the GABA(A) R were increased (P < 0.01, respectively) in the involved skin. Cells stained for GABA ligand were mostly macrophages with some lymphocytes, while cells stained for GABA(A) R were macrophages, neutrophils or lymphocytes. There was a positive correlation when comparing GABA ligand (P = 0.05) and GABA(A) R (P < 0.05) expressing inflammatory cells, with pruritus. The GABA ligand and its GABA(A) R may play a role for the pathogenesis of psoriasis as well as for pruritus in this disease.