Assessing cement injection behaviour in cancellous bone: An in vitro study using flow models
Assessing cement injection behaviour in cancellous bone: An in vitro study using flow models
复制标题
评估松质骨中的骨水泥注射行为：使用流动模型的体外研究
DOI：
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发表时间：
2014
影响因子：
2.9
通讯作者：
N. Kapur
中科院分区：
文献类型：
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作者：
Antony Bou;Alejandro López;C. Persson;R. Hall;N. Kapur
了解椎体成形术期间的骨水泥注射行为并准确预测椎体内的骨水泥放置是极具挑战性的。由于没有标准化的方法，我们提出了一种新的方法，使用可重复的和病理代表性的流动模型来研究水泥性能对注入行为的影响。将模型限制在上部玻璃窗和下部铝板之间，用骨髓替代物填充，然后以恒定流速（3 mL/min）注射（骨水泥混合后4、6和8 min）市售骨水泥（Simplex P、Opacity+、OsteopalV和Parallax）。使用测力传感器测量施加在注射器柱塞上的力并计算峰值压力。在注射过程中使用摄像机监测骨水泥流量，并在骨水泥到达模型边界时计算以下参数：到达边界的时间、填充面积和圆度。峰值压力与临床椎体成形术期间报告的峰值压力相当，并显示出随注射时间的类似增加。该研究强调了水泥配方和模型结构对注入行为的影响，并表明具有相似成分/粒度的水泥具有相似的流动行为，而引入缺陷减少了到达边界的时间，填充区域和圆度。所提出的方法提供了一种新的工具，通过可视化和定量分析的水泥蔓延在不同的时间间隔之间的各种水泥配方的快速，强大的区分。
Understanding the cement injection behaviour during vertebroplasty and accurately predicting the cement placement within the vertebral body is extremely challenging. As there is no standardized methodology, we propose a novel method using reproducible and pathologically representative flow models to study the influence of cement properties on injection behaviour. The models, confined between an upper glass window and a lower aluminium plate, were filled with bone marrow substitute and then injected (4, 6 and 8 min after cement mixing) with commercially available bone cements (SimplexP, Opacity+, OsteopalV and Parallax) at a constant flow rate (3 mL/min). A load cell was used to measure the force applied on the syringe plunger and calculate the peak pressure. A camera was used to monitor the cement flow during injection and calculate the following parameters when the cement had reached the boundary of the models: the time to reach the boundary, the filled area and the roundness. The peak pressure was comparable to that reported during clinical vertebroplasty and showed a similar increase with injection time. The study highlighted the influence of cement formulations and model structure on the injection behaviour and showed that cements with similar composition/particle size had similar flow behaviour, while the introduction of defects reduced the time to reach the boundary, the filled area and the roundness. The proposed method provides a novel tool for quick, robust differentiation between various cement formulations through the visualization and quantitative analysis of the cement spreading at various time intervals.