Fueling immunity: insights into metabolism and lymphocyte function.
Fueling immunity: insights into metabolism and lymphocyte function.
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DOI：
10.1126/science.1242454
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发表时间：
2013-10-11
期刊：
影响因子：
--
通讯作者：
Jones RG
中科院分区：
文献类型：
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作者：
Pearce EL;Poffenberger MC;Chang CH;Jones RG
淋巴细胞在活化后面临主要的代谢挑战。它们必须满足增加细胞增殖的生物能量和生物合成需求，并适应不断变化的环境条件，其中营养物质和氧气可能受到限制。免疫学中一个新兴的主题是代谢重编程和淋巴细胞活化是错综复杂的联系。然而，为什么T细胞采用特定的代谢程序，以及这些程序对T细胞功能和最终免疫结果的影响仍然不清楚。对肿瘤细胞代谢的研究为细胞增殖的重要代谢途径以及代谢物本身对信号转导和表观遗传编程的影响提供了有价值的见解。在这篇综述中，我们强调了关于增殖细胞中代谢重编程的新概念，并讨论了它们对T细胞命运和功能的潜在影响。
Lymphocytes face major metabolic challenges upon activation. They must meet the bioenergetic and biosynthetic demands of increased cell proliferation and also adapt to changing environmental conditions, in which nutrients and oxygen may be limiting. An emerging theme in immunology is that metabolic reprogramming and lymphocyte activation are intricately linked. However, why T cells adopt specific metabolic programs and the impact that these programs have on T cell function and, ultimately, immunological outcome remain unclear. Research on tumor cell metabolism has provided valuable insight into metabolic pathways important for cell proliferation and the influence of metabolites themselves on signal transduction and epigenetic programming. In this Review, we highlight emerging concepts regarding metabolic reprogramming in proliferating cells and discuss their potential impact on T cell fate and function.