NASOPHARYNGEAL COLONIZATION BY NONTYPABLE HAEMOPHILUS-INFLUENZAE IN CHILDREN - THE EFFECT OF SERUM BACTERICIDAL ANTIBODY
NASOPHARYNGEAL COLONIZATION BY NONTYPABLE HAEMOPHILUS-INFLUENZAE IN CHILDREN - THE EFFECT OF SERUM BACTERICIDAL ANTIBODY
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DOI：
10.1177/019459989110500309
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发表时间：
1991-09-01
影响因子：
3.4
通讯作者：
OGRA, PL
中科院分区：
文献类型：
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作者：
BERNSTEIN, JM;FADEN, HS;OGRA, PL
本文报告26例小儿血清杀菌抗体对NTHI定植的影响。血清杀菌抗体不能阻止NTHI在鼻咽部的定植。抗体检测53%之前，91%期间，100%后记录殖民。与定殖前（0.49 +/-0.51）相比，抗体的对数滴度在定殖期间（1.18 +/-0.56），p < 0.002;和定殖后（1.31 +/-0.29），p > 0.001显著更高。本文还讨论了分泌型伊加和鼻咽部正常植物群对致病菌的抑制作用。
The effect of serum bactericidal antibody on colonization with NTHI was studied in 26 children. Serum bactericidal antibody did not prevent colonization with NTHI in the nasopharynx. Antibody was detected in 53% before, 91% during, and 100% after documented colonization. The log titer of antibody was significantly higher during (1.18 +/- 0.56), p < 0.002; and after (1.31 +/- 0.29), p > 0.001 compared to before colonization (0.49 +/- 0.51). The roles of secretory IgA and normal nasopharyngeal flora in inhibiting pathogenic bacteria are discussed.