Association between SOD2 C47T polymorphism and lung cancer susceptibility: a meta-analysis
Association between SOD2 C47T polymorphism and lung cancer susceptibility: a meta-analysis
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SOD2 C47T 多态性与肺癌易感性之间的关联：荟萃分析
DOI：
10.1007/s13277-013-1127-y
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发表时间：
2014-02-01
期刊：
影响因子：
--
通讯作者：
Zhang, Gen-Sheng
中科院分区：
文献类型：
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作者：
Li, Na;Huang, Hua-Qiong;Zhang, Gen-Sheng
肺癌是世界上最常见的癌症之一，但其病因仍不清楚。超氧化物歧化酶2（SOD 2）在氧化应激中起重要作用，并可能参与肺癌的发展。SOD 2 C47 T多态性与肺癌风险的关系已被广泛研究，但以往的研究结果相互矛盾。我们进行了一项荟萃分析，以全面评估SOD 2 C47 T多态性与肺癌之间的关联。通过比值比（OR）和95%置信区间（95%CI）估计相关性。共确定了10项研究，包括5，146例病例和6，173例对照。结果表明，SOD 2基因C47 T多态性与肺癌的发生显著相关（T与C：OR = 0.88，95% CI = 0.83-0.93，P < 0.001; TT与CC：OR = 0.74，95% CI = 0.66-0.83，P < 0.001; TT与CC/CT：OR = 0.81，95%CI = 0.73-0.89，P < 0.001）。亚组分析表明，SOD 2 C47 T多态性与东亚人和高加索人的肺癌显著相关。总之，这项荟萃分析强烈表明SOD 2 C47 T多态性与肺癌显著相关。
Lung cancer is one of the most common cancers worldwide, but its etiology is still unclear. Superoxide dismutase 2 (SOD2) plays an essential role in oxidative stress and may be involved in the development of lung cancer. The association between SOD2 C47T polymorphism and lung cancer risk has been widely investigated, but the results of previous studies are contradictory. We conducted a meta-analysis to comprehensively assess the association between SOD2 C47T polymorphism and lung cancer. The association was estimated by odds ratio (OR) with 95 % confidence interval (95 % CI). A total of 10 studies with 5,146 cases and 6,173 controls were identified. The results showed that SOD2 C47T polymorphism was significantly associated with lung cancer (T versus C: OR = 0.88, 95 % CI = 0.83-0.93, P < 0.001; TT versus CC: OR = 0.74, 95 % CI = 0.66-0.83, P < 0.001; TT versus CC/CT: OR = 0.81, 95 % CI = 0.73-0.89, P < 0.001). Subgroup analysis by ethnicity suggested that SOD2 C47T polymorphism was significantly associated with lung cancer in both East Asians and Caucasians. Conclusively, this meta-analysis strongly suggests that SOD2 C47T polymorphism is significantly associated with lung cancer.