Exercise attenuates the increase in plasma monounsaturated fatty acids and high-density lipoprotein cholesterol but not high-density lipoprotein 2b cholesterol caused by high-oleic ground beef in women
Exercise attenuates the increase in plasma monounsaturated fatty acids and high-density lipoprotein cholesterol but not high-density lipoprotein 2b cholesterol caused by high-oleic ground beef in women
复制标题
DOI：
10.1016/j.nutres.2013.09.003
复制
发表时间：
2013-12-01
影响因子：
4.5
通讯作者：
Smith, Stephen B.
中科院分区：
文献类型：
--
作者：
Gilmore, L. Anne;Crouse, Stephen F.;Smith, Stephen B.
我们假设，饮食中的单不饱和脂肪酸（MUFA）和运动通过独立的机制增加高密度脂蛋白胆固醇（HDL-C），因此，单次高强度运动和高MUFA碎牛肉对HDL-C和心血管疾病的血液风险因素之间存在累加效应。17名绝经后妇女完成了一项双向交叉设计，其中他们每周食用5个114克的碎牛肉饼，持续两个6周的时间，中间间隔4周的洗脱期（习惯饮食）。碎牛肉饼含有21%的总脂肪，具有9.97（低MUFA）或12.72（高MUFA）g的总MUFA。在入组时、每6周饮食期结束时、4周洗脱期后和有氧运动期后24小时（75% VO 2峰值，2.07 MJ）采集血液。在绞细牛肉干预后，高MUFA绞细牛肉增加了血浆棕榈油酸和油酸、低密度脂蛋白（LDL）颗粒密度、HDL-C和HDL 2b-C（均P <0.05），而低MUFA绞细牛肉增加了LDL密度。在洗脱期（习惯性饮食）后，单次运动会增加血清LDL胆固醇，HDL-C和HDL 2a，降低TAG和油酸。在低MUFA绞细牛肉饮食后，运动增加了LDL大小和HDL密度，降低了LDL密度和极低密度脂蛋白胆固醇，但对HDL-C组分没有影响。在高MUFA绞细牛肉干预后，运动降低了棕榈油酸、油酸、HDL-C和HDL 2a-C，但不降低HDL 2b-C。与我们的假设相反，运动和高MUFA饮食的影响不是累加的;相反，运动减弱了高MUFA绞细牛肉对HDL-C和血浆MUFA的影响。高MUFA绞细牛肉和运动对HDL 2a-C和HDL 2b-C的不同影响表明，饮食和运动通过不同的机制影响HDL-C。(C)2013 Elsevier Inc. All rights reserved.
We hypothesized that dietary monounsaturated fatty acids (MUFA) and exercise increase high-density lipoprotein cholesterol (HDL-C) by independent mechanisms, so there would be additive effects between a single, intensive session of exercise and high-MUFA ground beef on HDL-C and blood risk factors for cardiovascular disease. Seventeen postmenopausal women completed a 2-way crossover design in which they consumed five 114-g ground beef patties per week for two 6-week periods separated by a 4-week washout (habitual diet) period. The ground beef patties contained 21% total fat with either 9.97 (low-MUFA) or 12.72 (high-MUFA) g total MUFA. Blood was taken at entry, at the end of each 6-week diet period, after the 4-week washout period, and 24 hours after aerobic exercise sessions (75% VO2peak, 2.07 MJ). After the ground beef intervention, the high-MUFA ground beef increased plasma palmitoleic acid and oleic acid, low-density lipoprotein (LDL) particle density, HDL-C, and HDL2b-C (all P < .05), whereas the low-MUFA ground beef increased LDL density. After the washout (habitual diet) period, the single exercise session increased serum LDL cholesterol, HDL-C, and HDL2a and decreased TAG and oleic acid. After the low-MUFA ground beef diet, exercise increased LDL size and HDL density and decreased LDL density and very low-density lipoprotein cholesterol, but had no effect on HDL-C fractions. After the high-MUFA ground beef intervention, exercise decreased palmitioleic acid, oleic acid, HDL-C, and HDL2a-C, but not HDL2b-C. Contrary to our hypothesis, the effects of exercise and a high-MUFA diet were not additive; instead, exercise attenuated the effects of the high-MUFA ground beef on HDL-C and plasma MUFAs. The differential effects of high-MUFA ground beef and exercise on HDL2a-C and HDL2b-C indicate that diet and exercise affect HDL-C by different mechanisms. (C) 2013 Elsevier Inc. All rights reserved.