Improving AML Classification Using Splicing Signatures.
Improving AML Classification Using Splicing Signatures.
复制标题
使用拼接签名改进 AML 分类。
DOI：
10.1158/1078-0432.ccr-20-1021
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Bowman,TeresaV
中科院分区：
文献类型：
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作者：
Bowman,TeresaV
剪接体成分突变在骨髓增生异常综合征中很普遍，但在急性髓性白血病（AML）中较少。然而，异常剪接在AML中是多产的，这表明不受控制的剪接可能广泛地促进了肿瘤的发生。升高的应激反应与髓系恶性肿瘤剪接功能障碍相关，代表了潜在的新治疗靶点。参见阿南德等人的相关文章，第3597页
Mutations in spliceosomal components are prevalent in myelodysplastic syndromes, but less so in acute myeloid leukemia (AML). However, aberrant splicing is prolific in AML, suggesting deregulated splicing could contribute broadly to tumorigenesis. Elevated stress responses correlate with splicing dysfunction across myeloid malignancies, representing potentially novel therapeutic targets.See related article by Anande et al., p. 3597