ToF-SIMS imaging of a polymer microarray prepared using ink-jet printing of acrylate monomers
ToF-SIMS imaging of a polymer microarray prepared using ink-jet printing of acrylate monomers
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DOI：
10.1002/sia.5042
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发表时间：
2013-01-01
影响因子：
1.7
通讯作者：
Alexander, Morgan R.
中科院分区：
文献类型：
--
作者：
Celiz, Adam D.;Hook, Andrew L.;Alexander, Morgan R.
聚合物微阵列是高通量材料发现的强大样品格式。我们描述了一种通过喷墨打印制备的聚合物微阵列，用于筛选新型生物材料。喷墨印刷具有优于其他印刷技术的优点，包括避免与表面接触，防止对易碎基材的损坏，以及控制液滴体积以控制沉积的材料量。我们研究了一种喷墨打印单体溶液库的方法，这些单体溶液随后原位聚合以形成聚合物微阵列。使用飞行时间二次离子质谱法的聚合物微阵列的成像被用来映射组成单体的特定离子特征，并确定每个聚合物的表面存在哪些化学官能团。这在确定阵列的质量和理解在材料和生物有机体之间的界面处发生的相互作用方面特别重要。版权所有（C）2012约翰威利父子有限公司
Polymer microarrays are a powerful sample format for high-throughput materials discovery. We describe a polymer microarray prepared via ink-jet printing for the purpose of screening novel biomaterials. Ink-jet printing has advantages over other printing techniques including avoiding contact with the surface, preventing damage to fragile substrates, and the control of the drop volume to control the amount of material deposited. We investigate a method for ink-jet printing a library of monomer solutions, which are subsequently polymerized in-situ to form the polymer microarray. Imaging of the polymer microarray using time-of flight secondary ion mass spectrometry is employed to map specific ions characteristic of the constituent monomers and identify which chemical functionalities are present at the surface of each polymer. This is particularly important in determining the quality of the array and understanding the interactions that occur at the interface between a material and a biological organism. Copyright (C) 2012 John Wiley & Sons, Ltd.