Toxicant exposure and the developing brain: A systematic review of the structural and functional MRI literature.
Toxicant exposure and the developing brain: A systematic review of the structural and functional MRI literature.
复制标题
有毒物暴露和大脑发育：结构和功能 MRI 文献的系统回顾。
DOI：
10.1016/j.neubiorev.2022.105006
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发表时间：
2023
影响因子：
8.2
通讯作者：
Gaffrey,MichaelS
中科院分区：
文献类型：
--
作者：
Fowler,CarinaH;Bagdasarov,Armen;Camacho,NicolasL;Reuben,Aaron;Gaffrey,MichaelS
全世界的青年经常接触污染物和化学品（即，有毒物质）可能会干扰健康的大脑发育，MRI研究的激增已经开始描述这些暴露的神经生物学后果。在此，根据PRISMA指南，对已知或疑似神经生物学影响的毒物的发育MRI研究进行了系统综述。协会进行了审查，为9个有毒类别，包括金属，空气污染和阻燃剂。在识别的1264项研究中，46项符合纳入标准。定性综合显示，大多数研究：（1）调查了空气污染物或金属，（2）评估了产前暴露，（3）评估了儿童中期后期的大脑，（4）在北美或西欧进行，（5）从现有的队列研究中抽取样本，（6）自2017年以来已发表。考虑到MRI测量、毒物测量和年龄组评估的实质性异质性，需要对本文综述的所有毒物进行更多研究。未来的研究还应包括更大的样本，采用个人接触监测，研究世界不同地区的独立样本，并评估有毒混合物。
Youth worldwide are regularly exposed to pollutants and chemicals (i.e., toxicants) that may interfere with healthy brain development, and a surge in MRI research has begun to characterize the neurobiological consequences of these exposures. Here, a systematic review following PRISMA guidelines was conducted on developmental MRI studies of toxicants with known or suspected neurobiological impact. Associations were reviewed for 9 toxicant classes, including metals, air pollution, and flame retardants. Of 1264 identified studies, 46 met inclusion criteria. Qualitative synthesis revealed that most studies: (1) investigated air pollutants or metals, (2) assessed exposures prenatally, (3) assessed the brain in late middle childhood, (4) took place in North America or Western Europe, (5) drew samples from existing cohort studies, and (6) have been published since 2017. Given substantial heterogeneity in MRI measures, toxicant measures, and age groups assessed, more research is needed on all toxicants reviewed here. Future studies should also include larger samples, employ personal exposure monitoring, study independent samples in diverse world regions, and assess toxicant mixtures.