Inhibition of fungal cell wall synthesizing enzymes by trans-cinnamaldehyde
Inhibition of fungal cell wall synthesizing enzymes by trans-cinnamaldehyde
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DOI：
10.1271/bbb.64.1061
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发表时间：
2000-05-01
影响因子：
1.6
通讯作者：
Rhee, YH
中科院分区：
文献类型：
--
作者：
Bang, KH;Lee, DW;Rhee, YH
研究了反式肉桂醛（CA）对酿酒酵母细胞壁合成酶的抑制作用。发现该化合物是β-（1，3）-葡聚糖合酶的非竞争性抑制剂和几丁质合酶1的混合抑制剂，其50%抑制浓度（IC 50）分别为0.84和1.44 mM。几丁质酶2和3对CA的敏感性低于几丁质合成酶1。CA可作为细胞壁抑制剂的模型化合物用于开发有效的抗真菌剂。
This study examined the inhibitory effects of trans-cinnamaldehyde (CA), an aromatic aldehyde derived from Cinnamomi Cortex, on Saccharomyces cerevisiae cell wall synthesizing enzymes in vitro. This compound was found to be a noncompetitive inhibitor of beta-(1,3)-glucan synthase and a mixed inhibitor of chitin synthase 1 with 50% inhibitory concentrations (IC50) of 0.84 and 1.44 mM, respectively. Chitin synthases 2 and 3 were less sensitive than chitin synthase 1 to CA. CA can be useful as a model compound of cell wall inhibitors for the development of effective antifungal agents.