Upregulation of glucose metabolism by granulocyte-monocyte colony-stimulating factor.
Upregulation of glucose metabolism by granulocyte-monocyte colony-stimulating factor.
复制标题
粒细胞-单核细胞集落刺激因子上调葡萄糖代谢。
DOI：
10.1016/0024-3205(91)90175-b
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发表时间：
1991
期刊：
影响因子：
6.1
通讯作者：
Spitzer,JJ
中科院分区：
文献类型：
--
作者：
Schuler,A;Spolarics,Z;Lang,CH;Bagby,GJ;Nelson,S;Spitzer,JJ
Alterations of glucose metabolism were investigated for 6 hours following an intraarterial injection of murine recombinant granulocyte-monocyte colony-stimulating factor (GM-CSF) (30 μg/k body weight). GM-CSF resulted in a transient elevation of plasma glucose. The rate of whole body glucose appearance, as measured by infusion of [6-3H]glucose, was increased by about 10 % between 0.5 and 3 hours following GM-CSF injection.In vivoglucose utilization of individual tissues was investigated by the tracer 2-deoxyglucose technique. At 30 min, GM-CSF increased glucose utilization by 80–90 % in liver and lung, and 50–60 % in skin and spleen. At 3 and 6 hours, glucose utilization by these tissues returned toward control levels except for lung. There was a 40–50 % increase in glucose utilization by skeletal muscle 30 min after GM-CSF which was sustained for 6 hours. Glucose utilization of testis, ileum and kidney did not change significantly. Plasma concentrations of insulin, glucagon and tumor necrosis factor were not altered in response to GM-CSF. These findings indicate that some of the acute metabolic effects of a short-term administration of GM-CSF are observed in macrophage-rich tissues, and suggest that GM-CSF may be involved in the metabolic upregulation of immunologically active tissues.
