EXPRESSION OF C-FOS IMMUNOREACTIVITY IN THE HYPOTHALAMIC MAGNOCELLULAR NEURONS DURING CHRONIC OSMOTIC STIMULATIONS
EXPRESSION OF C-FOS IMMUNOREACTIVITY IN THE HYPOTHALAMIC MAGNOCELLULAR NEURONS DURING CHRONIC OSMOTIC STIMULATIONS
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DOI：
10.1016/0304-3940(94)91078-2
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发表时间：
1994-07-04
影响因子：
2.5
通讯作者：
KIYOHARA, T
中科院分区：
文献类型：
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作者：
MIYATA, S;NAKASHIMA, T;KIYOHARA, T
腹腔注射高渗氯化钠溶液后，在大鼠下丘脑视上核（SON）和室旁核（PVN）的大细胞神经元中，出现了c-fos蛋白的瞬时免疫反应。相反，c-fos阳性大细胞神经元持续观察到在SON和PVN的大鼠，这是慢性刺激的饮用高渗NaCl溶液，而不是水或水剥夺。在慢性渗透刺激后允许饮用自来水24小时的动物中c-fos免疫反应性被消除。这些结果表明，c-fos蛋白的持续表达与下丘脑大细胞神经元的神经可塑性密切相关。
The immunoreactivity of c-fos protein was transiently detected in magnocellular neurons of the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of the rat hypothalamus after intraperitoneal injection of hypertonic NaC1 solution. In contrast, c-fos-positive magnocellular neurons were persistently observed in the SON and PVN of the rats which were chronically stimulated by the drinking of hypertonic NaC1 solution instead of water or by water deprivation. c-fos immunoreactivity was eliminated in the animals which were allowed to drink tap water for 24 h following the chronic osmotic stimulations. These results suggest that persistent expression of c-fos protein is closely associated with the neural plasticity of the hypothalamic magnocellular neuron.