Prevalence, awareness and treatment of cardiovascular risk factors in patients at high risk of atherothrombosis in Japan - Results from domestic baseline data of the REduction of atherotherombosis for continued health (REACH) registry
Prevalence, awareness and treatment of cardiovascular risk factors in patients at high risk of atherothrombosis in Japan - Results from domestic baseline data of the REduction of atherotherombosis for continued health (REACH) registry
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DOI：
10.1253/circj.71.995
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发表时间：
2007-07-01
影响因子：
3.3
通讯作者：
Ikeda, Yasuo
中科院分区：
文献类型：
--
作者：
Yamazaki, Tsutomu;Goto, Shinya;Ikeda, Yasuo
背景动脉血栓形成持续健康减少(REACH)登记是一项针对动脉粥样硬化性血栓患者或有动脉粥样硬化性血栓患者风险的国际观察性研究。方法和结果在全球范围内招募了近68,000名门诊患者，其中5,193名在日本。在日本患者中，83.7%的患者已有血管疾病(有症状)，16.3%的患者仅有危险因素(无症状)。在有症状的患者中，14.0%的患者动脉粥样硬化血栓病变位于I个以上血管床上，0.8%的患者病变位于脑、心脏和外周动脉三个区域。在有症状的患者中，其他动脉粥样硬化血栓形成危险因素的流行与血管病变无关。肥胖的比例分别为10.6%和42%。1%的患者分别符合国家胆固醇教育计划和日本指南。对危险因素的药物干预不足：只有37.7%的糖尿病患者接受了降糖药物治疗，79.6%的高血压患者使用了降压药，74.0%的患者接受了抗血小板药物治疗。他汀类药物(44.1%)和阿司匹林(54.7%)的使用率低于REACH全球患者。结论REACH的日本患者与全球人群有许多相似之处，但也有一些重要的差异。长期随访将确定这些因素对动脉粥样硬化血栓形成事件发展的影响。
Background The REduction of Atherothrombosis for Continued Health (REACH) Registry is an international observational study of patients with, or at risk of, atherothrombotic disease. Japanese patients were analyzed to clarify national prevalence and treatment.Methods and Results Almost 68,000 outpatients were recruited worldwide with 5,193 in Japan. Among the Japanese patients, 83.7% had established vascular disease (symptomatic) and 16.3% had risk factors only (asymptomatic). Of the symptomatic patients, 14.0% had atherothrombotic lesions in more than I vascular bed, with 0.8% having lesions in 3 areas: brain, heart, and peripheral arteries. The prevalence of additional atherothrombotic risk factors among symptomatic patients was independent of the vascular lesion. Obesity was recorded in 10.6% and 42. 1 % of patients according to the National Cholesterol Education Program and Japanese guidelines, respectively. Pharmacologic intervention for risk factors was inadequate: only 37.7% of diabetic patients received antidiabetic medication, 79.6% of hypertensive patients used antihypertensives, and 74.0% received antiplatelet agents. The use of statins (44.1 %) and aspirin (54.7%) was less common than seen in REACH globally.Conclusions Japanese patients enrolled in REACH share many similarities with the global population, but with some important differences. Long-term follow-up will determine the impact of these factors on the development of atherothrombotic events.