The gene regulatory control of sea urchin gastrulation
The gene regulatory control of sea urchin gastrulation
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DOI：
10.1016/j.mod.2020.103599
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发表时间：
2020-06-01
影响因子：
2.6
通讯作者：
Ettensohn, Charles A.
中科院分区：
文献类型：
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作者：
Ettensohn, Charles A.
与海胆原肠形成有关的细胞行为已经得到了很好的描述。最近，在阐明基因调控网络(GRN)方面取得了相当大的进展，GRN是该实验模型中早期胚胎区域规范的基础。这项审查综合了这两种工作方式的信息。我讨论了在海胆原肠形成过程中发生的主要细胞运动，重点是运动的分子效应器，并总结了我们目前对这些效应器上游的基因调控电路的理解。一个案例是GRN生物学可以提供原肠形成的因果解释，尽管还需要在生物组织的几个水平上进行额外的分析，以提供对这一复杂的形态发生过程的更深层次的理解。
The cell behaviors associated with gastrulation in sea urchins have been well described. More recently, considerable progress has been made in elucidating gene regulatory networks (GRNs) that underlie the specification of early embryonic territories in this experimental model. This review integrates information from these two avenues of work. I discuss the principal cell movements that take place during sea urchin gastrulation, with an emphasis on molecular effectors of the movements, and summarize our current understanding of the gene regulatory circuitry upstream of those effectors. A case is made that GRN biology can provide a causal explanation of gastrulation, although additional analysis is needed at several levels of biological organization in order to provide a deeper understanding of this complex morphogenetic process.