Diabetes is not prevented by Foxp3-transduced CD4(+)T cells under the IL-12Rbeta2 promoter control.
Diabetes is not prevented by Foxp3-transduced CD4(+)T cells under the IL-12Rbeta2 promoter control.
复制标题
IL-12Rbeta2启动子控制下的Foxp3转导的CD4(+)T细胞不能预防糖尿病。
DOI：
10.1016/j.molimm.2008.05.016
复制
发表时间：
2008-08
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
--
作者：
Our previous studies have shown that Foxp3 under the control of IFN-γ promoter (IγP-Foxp3) converts pathogenic CD4+Th1 cells into regulatory T cells (Tregs), which control diabetes in non-obese diabetic (NOD) mice. Here, we tested the other hypothesis that transient expression of Foxp3 as controlled by the transient expression of IL-12Rβ2 during Th1 cell derivation is sufficient to convert cells to Tregs. Foxp3, under the control of IL-12Rβ2 promoter (Iβ2P), was lentivirally transduced into naïve CD4+T cells from NOD mice. Iβ2P-Foxp3-transduced CD4+T cells could not effectively suppress the incidence of diabetes when transferred into NOD mice. Furthermore, we found that Iβ2P-Foxp3-transduced CD4+T cells, stimulated by a high dose of autoantigen, did not suppress CD4+T cell activation, produce CD4+Foxp3+Tregs, and up-regulate CTLA4 expression. These results suggest that Iβ2P cannot mediate Foxp3 to convert pathogenic CD4+Th1 cells into Tregs which control diabetes in NOD mice.
登录
查看更多内容
DOI：
--
发表时间：
2003
期刊：
--
影响因子：
--
作者：
Niclas Jonzén;Andreas Lindén;Torbjørn Ergon;E. Knudsen;J. Vik;Diego Rubolini;D. Piacentini;
通讯作者：
Niclas Jonzén;Andreas Lindén;Torbjørn Ergon;E. Knudsen;J. Vik;Diego Rubolini;D. Piacentini;
影响因子：
15.3
作者：
Szabo, SJ;Dighe, AS;Gubler, U;Murphy, KM
通讯作者：
Murphy, KM
影响因子：
4.4
作者：
Han, GC;Li, Y;Shen, BF
通讯作者：
Shen, BF
DOI：
10.1038/sj.mt.6300208
发表时间：
2007-08
期刊：
Molecular therapy : the journal of the American Society of Gene Therapy
影响因子：
--
作者：
R. Wang;G. Han;Jianan Wang;Lun Song;Guojiang Chen;R. Xu;Ming Yu;J. Qian;B. Shen;Yan Li
通讯作者：
R. Wang;G. Han;Jianan Wang;Lun Song;Guojiang Chen;R. Xu;Ming Yu;J. Qian;B. Shen;Yan Li
影响因子：
64.8
作者：
KAUFMAN, DL;CLARESALZLER, M;LEHMANN, PV
通讯作者：
LEHMANN, PV