Long-term serological outcome of infants who received frozen-thawed milk from human T-lymphotropic virus type-I positive mothers
Long-term serological outcome of infants who received frozen-thawed milk from human T-lymphotropic virus type-I positive mothers
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DOI：
10.1111/j.1447-0756.2004.00227.x
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发表时间：
2004-12-01
影响因子：
1.6
通讯作者：
Toyama, T
中科院分区：
文献类型：
--
作者：
Ando, Y;Ekuni, Y;Toyama, T
目的：人类嗜T淋巴细胞病毒I型（HTLV-I）在喂养过程中通过母乳感染。方法：对HTLV-I阳性母亲的母乳进行冻融处理，对冻融后母乳的HTLV-I感染性进行长期随访调查。喂养冷冻解冻母乳的婴儿直到1岁才出现HTLV-I抗体阳性，结论：冻融处理可以消除母乳中HTLV-I的感染性，HTLV-I携带者可以间接地用冻融母乳喂养婴儿来预防HTLV-I感染。
Aim: Human T-lymphotropic virus type-I (HTLV-I) infection occurs via mothers' milk during feeding. However, freeze-thaw processing can eliminate the infectivity of the mother's milk of HTLV-I carriers.Methods: A long-term follow-up survey was conducted to investigate the HTLV-I infectivity of frozen-thawed mothers' milk among infants whose mothers were HTLV-I seropositive.Results: Infants fed frozen-thawed mothers' milk did not become HTLV-I antibody-positive up until 1 year old, and all children followed up until an age of 11-12 years were antibody negative.Conclusions: This study showed that freeze-thaw processing can eliminate the HTLV-I infectivity of mothers' milk, and that HTLV-I carriers can indirectly feed their infants using frozen-thawed mothers' milk as a way to prevent HTLV-I infection.