Riquiqui and minibrain are regulators of the hippo pathway downstream of Dachsous.
Riquiqui and minibrain are regulators of the hippo pathway downstream of Dachsous.
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DOI：
10.1038/ncb2829
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发表时间：
2013-10
影响因子：
21.3
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中科院分区：
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非典型钙粘蛋白Fat（Ft）和Dachsous（Ds）通过Salvador-Warts-Hippo（SWH）途径控制组织生长，并且还调节平面细胞极性（PCP）、近端-远端（PD）模式和形态发生。Ft和Ds参与相互信号传导，因为这两种蛋白质可以作为彼此的受体和配体。Ft和Ds的细胞内结构域（ICD）调节关键SWH途径转录共激活蛋白Yorkie（Yki）的活性。来自Ft ICD的信号传导被很好地表征，并且通过调节Yk 1抑制性激酶Warts（Wts）的丰度来控制组织生长。在这里，我们描述了两个新的调节SWH通路的功能下游的Ds ICD：WD 40域蛋白Riquiqui（Riq）和DYRK家族激酶Minibrain（Mnb）。Ds与Riq物理相互作用，Riq与Mnb和Wts两者形成复合物。Riq和Mnb通过刺激Wts的磷酸化依赖性抑制来促进Ykidendent组织生长。因此，我们描述了一个新的分支的SWH途径，促进组织生长下游的Ds。
The atypical cadherins, Fat (Ft) and Dachsous (Ds) control tissue growth via the Salvador-Warts-Hippo (SWH) pathway, and also regulate planar cell polarity (PCP), proximo-distal (PD) patterning and morphogenesis. Ft and Ds engage in reciprocal signalling as both proteins can serve as receptor and ligand for each other. The intracellular domains (ICD) of Ft and Ds regulate activity of the key SWH pathway transcriptional co-activator protein Yorkie (Yki). Signalling from the Ft ICD is well characterized and controls tissue growth by regulating abundance of the Ykirepressive kinase Warts (Wts). Here we describe two new regulators of the SWH pathway that function downstream of the Ds ICD: the WD40 domain protein Riquiqui (Riq) and the DYRK-family kinase Minibrain (Mnb). Ds physically interacts with Riq, which forms a complex with both Mnb and Wts. Riq and Mnb promote Ykidependent tissue growth by stimulating phosphorylation-dependent inhibition of Wts. Thus, we describe a new branch of the SWH pathway that promotes tissue growth downstream of Ds.