Fast multiecho balanced SSFP metabolite mapping of 1H and hyperpolarized 13C compounds
Fast multiecho balanced SSFP metabolite mapping of 1H and hyperpolarized 13C compounds
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DOI：
10.1007/s10334-009-0169-z
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发表时间：
2009-08-01
影响因子：
2.3
通讯作者：
Wieben, Oliver
中科院分区：
文献类型：
--
作者：
Leupold, Jochen;Mansson, Sven;Wieben, Oliver
研究基于多回波平衡稳态自由旋进（bSSFP）的快速化学位移映射超极化C-13代谢物的可行性。与普通化学位移成像（CSI）相比，总体目标是减少总成像时间并提高空间分辨率。采用多回波bSSFP序列结合迭代重建算法。H-1实验进行phantomerase和人类志愿者，以研究该方法的可行性的系统与代谢物的地图，是事先已知的。C-13实验在猪体内进行，其中CSI图像也用于比较。成功地获得了三个和四个不同H-1共振频率的化学位移图像以及多达五个超极化C-13代谢物的化学位移图像。基于多回波平衡SSFP的快速代谢物作图结合迭代重建方法可以成功地分离几个H-1共振频率。1共振和超极化C-13代谢物。
To investigate the feasibility of multiecho balanced steady-state free precession (bSSFP)-based fast chemical shift mapping hyperpolarized C-13 metabolites. The overall goal was to reduce total imaging time and to increase spatial resolution compared to common chemical shift imaging (CSI).A multiecho bSSFP sequence in combination with an iterative reconstruction algorithm was implemented. H-1 experiments were performed on phantoms and on a human volunteer in order to investigate the feasibility of the method on a system with metabolite maps that are known beforehand. C-13 experiments were performed in vivo on pigs, where CSI images were acquired also for comparison.Chemical shift images of three and four distinct H-1 resonance frequencies as well as chemical shift images of up to five hyperpolarized C-13 metabolites were successfully obtained.Fast metabolite mapping based on multiecho balanced SSFP in combination with an iterative reconstruction approach could successfully separate several H-1 resonances and hyperpolarized C-13 metabolites.