Differential involvement of serotonin and dopamine systems in cost-benefit decisions about delay or effort
Differential involvement of serotonin and dopamine systems in cost-benefit decisions about delay or effort
复制标题
DOI：
10.1007/s00213-004-2059-4
复制
发表时间：
2005-05-01
影响因子：
3.4
通讯作者：
Bannerman, DM
中科院分区：
文献类型：
--
作者：
Denk, F;Walton, ME;Bannerman, DM
基本原理：虽然评估多巴胺在努力-回报决策中的作用的任务与那些关注5-羟色胺在冲动选择中的作用的任务相似，因为两者都需要分析可能行动的成本和收益，但它们从未被直接比较过。目的：这项研究调查了血清素和多巴胺在两种成本效益模式中的参与，一种是延迟成本，另一种是体力劳动成本。方法：16只大鼠在T-迷宫任务中进行训练，在高和低奖励臂之间进行选择。在一个版本中，高奖励臂被障碍物阻挡，在另一个版本中，高奖励的交付延迟了15 s。血清素和多巴胺功能分别使用全身性pCPA和氟哌啶醇注射进行操作。结果：氟哌啶醇处理的大鼠不太倾向于付出更多的努力或支持延迟更高的奖励。pCPA对大鼠在努力任务中的表现没有影响，但显著增加了大鼠对立即但较小奖励的偏好。在大多数试验中，当延迟或努力成本在高和低奖励臂中匹配时，所有动物（药物治疗和对照）都选择高奖励臂。结论：参与不同类型成本效益决策的神经递质系统之间存在分离。虽然多巴胺能系统需要对努力和延迟做出决定，但多巴胺能系统只需要对后者做出决定。
Rationale: Although tasks assessing the role of dopamine in effort-reward decisions are similar to those concerned with the role of serotonin in impulsive choice in that both require analysis of the costs and benefits of possible actions, they have never been directly compared. Objectives: This study investigated the involvement of serotonin and dopamine in two cost-benefit paradigms, one in which the cost was delay and the other in which it was physical effort. Methods: Sixteen rats were trained on a T-maze task in which they chose between high and low reward arms. In one version, the high reward arm was obstructed by a barrier, in the other, delivery of the high reward was delayed by 15 s. Serotonin and dopamine function were manipulated using systemic pCPA and haloperidol injections, respectively. Results: Haloperidol-treated rats were less inclined either to exert more effort or to countenance a delay for a higher reward. pCPA had no effect on the performance of the rats on the effortful task, but significantly increased the rats' preference for an immediate but smaller reward. All animals ( drug treated and controls) chose the high reward arm on the majority of trials when the delay or effort costs were matched in both high and low reward arms. Conclusion: A dissociation was found between the neurotransmitter systems involved in different types of cost-benefit decision making. While dopaminergic systems were required for decisions about both effort and delay, serotonergic systems were only needed for the latter.