Functional Neuroimaging of Breastfeeding Analgesia by Multichannel Near-Infrared Spectroscopy
Functional Neuroimaging of Breastfeeding Analgesia by Multichannel Near-Infrared Spectroscopy
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DOI：
10.1159/000353386
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发表时间：
2013-01-01
期刊：
影响因子：
2.5
通讯作者：
Demarini, Sergio
中科院分区：
文献类型：
--
作者：
Bembich, Stefano;Davanzo, Riccardo;Demarini, Sergio
背景：新生儿感知疼痛，在疼痛过程中使用了几种非药物镇痛方法。双通道近红外光谱（NIRS）已经证实，新生儿体感觉皮层的激活与无镇痛的疼痛过程有关。目的：评估健康足月新生儿在两种非药物镇痛干预（即葡萄糖溶液和母乳喂养）中对疼痛过程的皮质和行为反应。方法：采用多通道近红外光谱法（NIRS）观察两组（n = 30）新生儿刺足时葡萄糖和母乳喂养对疼痛相关新生儿皮质活动的影响。皮质激活是通过氧合血红蛋白的变化来确定的。新生儿疼痛表达通过有效的量表进行评估。结果：葡萄糖溶液对新生儿皮质活动无显著影响，而母乳喂养的新生儿则表现出广泛的皮质激活。母乳喂养的新生儿显示行为更少痛苦的表情。结论：葡萄糖与皮质无明显的激活相关，可能在皮质水平上干扰疼痛相关反应。相反，母乳喂养镇痛与广泛性皮质激活有关，可能通过多感觉刺激起作用，可能是压倒性的痛觉。巴塞尔S. Karger股份有限公司版权所有
Background: Newborns perceive pain, and several non-pharmacologic analgesic methods have been used during painful procedures. Activation of the neonatal somatosensory cortex, in association with a painful procedure without analgesia, has been demonstrated by two-channel near-infrared spectroscopy (NIRS). Objectives: To evaluate both cortical and behavioural responses of healthy term newborns to a painful procedure during two non-pharmacologic analgesic interventions, i.e. glucose solution and breastfeeding. Methods: The effects of glucose and breastfeeding on pain-associated neonatal cortical activity were studied in two groups (n = 30) by multichannel NIRS during a heel prick. Cortical activation was identified by variations in oxygenated haemoglobin. Neonatal pain expression was assessed by a validated scale. Results: No significant variations in cortical activity emerged using glucose solution, whereas breastfed newborns showed widespread cortical activation. Breastfed neonates showed significantly less behavioural pain expression. Conclusions: Glucose is associated with no significant cortical activation and may interfere with pain-associated response at the cortical level. Conversely, breastfeeding analgesia is associated with generalized cortical activation and may act by multisensory stimulation, possibly overwhelming pain perception. Copyright (C) 2013 S. Karger AG, Basel