Physical limits to magnetogenetics
Physical limits to magnetogenetics
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DOI：
10.7554/elife.17210
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发表时间：
2016-08-16
期刊：
影响因子：
7.7
通讯作者：
Meister, Markus
中科院分区：
文献类型：
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作者：
Meister, Markus
这是对磁场如何影响生物分子和细胞的分析。这是由一系列有关生物系统中磁性的重要报告推动的。第一个声称已经鉴定出一种蛋白质复合物，其作用类似于罗盘针，可以引导动物的磁性方向（Qin 等人，2016）。另外两篇文章报道了通过将铁蛋白附着到离子通道蛋白上，然后牵引铁蛋白或用磁场加热它来对膜电导进行磁控制（Stanley 等人，2015 年；Wheeler 等人，2016 年）。在这里，我认为这些主张与基本物理定律相冲突。差异很大：从 5 到 10 个对数单位。如果所报告的现象确实发生，那么它们的原因一定与作者提出的完全不同。人们发现蛋白质复合物的顺磁性质严重限制了它们在磁敏感细胞工程中的应用。
This is an analysis of how magnetic fields affect biological molecules and cells. It was prompted by a series of prominent reports regarding magnetism in biological systems. The first claims to have identified a protein complex that acts like a compass needle to guide magnetic orientation in animals (Qin et al., 2016). Two other articles report magnetic control of membrane conductance by attaching ferritin to an ion channel protein and then tugging the ferritin or heating it with a magnetic field (Stanley et al., 2015; Wheeler et al., 2016). Here I argue that these claims conflict with basic laws of physics. The discrepancies are large: from 5 to 10 log units. If the reported phenomena do in fact occur, they must have causes entirely different from the ones proposed by the authors. The paramagnetic nature of protein complexes is found to seriously limit their utility for engineering magnetically sensitive cells.