Percent infarct mapping:: An R1-map-based CE-MRI method for determining myocardial viability distribution
Percent infarct mapping:: An R1-map-based CE-MRI method for determining myocardial viability distribution
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DOI：
10.1002/mrm.20979
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发表时间：
2006-09-01
影响因子：
3.3
通讯作者：
Elgavishi, Gabriel A.
中科院分区：
文献类型：
--
作者：
Suranyi, Pal;Kiss, Pal;Elgavishi, Gabriel A.
存活检测对于心肌梗死（MI）的管理至关重要。基于信号强度（SI）的MRI方法可能高估体内梗死面积。与SI相反，纵向弛豫速率增强（Δ R-1）是与造影剂（CA）的浓度成线性比例的内在参数。在存在梗塞-avid持续性CA（PCA）的情况下确定Δ R-1允许确定梗塞组织的每体素百分比。本文介绍了一种基于Delta R-1的CE-MRI方法，称为梗死百分比标测（PIM），用于定量延迟PCA累积后的心肌存活性。在犬MI模型（N = 6）中，使用持续性CA（PCA）生成PIM，并使用氯化三苯基四唑（TTC）组织化学进行验证。在PCA给药后24和48小时，使用具有多个反转时间（TI）的反转恢复（IR）生成整个左心室（LV）的逐体素R-1图。PI值逐体素计算。使用PIM确定的每切片PI（PIS）与相应的基于TTC的值之间存在显著相关性（P < 0.01，R = 0.97）。在24小时和48小时，PIM与TTC的PIS的中位偏差仅为1.01%和-0.53%，24小时和48小时与LV的真实梗死分数（IF）的中位偏差分别为1.23%和0.49%。PIM 24小时和PIM 48小时之间无显著差异。基于Delta R-1的PIM是一种准确且可重复的定量心肌存活分布的方法，从而增强了CE-MRI的临床实用性。
Viability detection is crucial for the management of myocardial infarction (MI). Signal intensity (SI)-based MRI methods may overestimate infarct size in vivo. In contrast to SI, the longitudinal relaxation-rate enhancement (Delta R-1) is an intrinsic parameter that is linearly proportional to the concentration of contrast agent (CA). Determining Delta R-1 in the presence of an infarct-avid persistent CA (PCA) allows determination of the per-voxel percentage of infarcted tissue. Introduced here is a Delta R-1-based CE-MRI method, termed percent infarct mapping (PIM), for quantifying myocardial viability following delayed PCA accumulation. In a canine MI model (N = 6), PIMs were generated using a persistent CA (PCA) and validated using triphenyltetrazoliumchloride (TTC) histochemistry. Voxel-by-voxel R-1 maps of the entire left ventricle (LV) were generated 24 and 48 hr after PCA administration using inversion recovery (IR) with multiple inversion times (TIs). PI values were calculated voxel by voxel. Significant correlations (P < 0.01, R = 0.97) were obtained for PI per slice (PIS) determined using PIM vs. corresponding TTCbased values. Median deviations of PIS with PIM from that with TTC were only 1.01% and -0.53%, at 24 hr and 48 hr. Median deviations from the true infarction fraction (IF) were 1.23% and 0.49% of LV at 24 hr and 48 hr, respectively. No significant difference was found between PIM24 hr and PIM48 hr. Delta R-1-based PIM is an accurate and reproducible method for quantifying myocardial viability distribution, and thus enhances the clinical utility of CE-MRI.