The in vivo influence of white matter fiber orientation towards B0 on T2*in the human brain
The in vivo influence of white matter fiber orientation towards B0 on T2*in the human brain
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DOI：
10.1002/nbm.1534
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发表时间：
2010-11-01
影响因子：
2.9
通讯作者：
Klose, U.
中科院分区：
文献类型：
--
作者：
Bender, B.;Klose, U.
众所周知，在较高场强下，T2* 加权图像在白质纤维束中显示出广泛的异质性。这种现象的基础仍在讨论中，因为许多因素，如铁浓度、髓鞘形成和组织微观结构，可能会影响弛豫时间此外，与主磁场相关的纤维方向似乎会影响 T2* 弛豫时间。在这项研究中，扩散张量成像和 T2* 对 7 名头部处于正常和倾斜位置的受试者进行测量结果表明，纤维方向对人脑中的 12* 有很大影响，平均 T2* 值从垂直方向 B-0 的 49 毫秒变化到平行方向 B-0 的 57 毫秒。尽管如此，在任何朝向 B-0 的方向上，T2* 时间都显示出各种各样的值 版权所有 (C) 2010 John Wiley & 儿子有限公司
It is well known that, at higher field strength, T2*-weighted images show an extensive heterogeneity in white matter fiber bundles The basis of this phenomenon is still under discussion, as many factors, such as iron concentration, myelination and tissue microstructure, could influence relaxation times Furthermore, fiber direction in relation to the main magnetic field seems to influence T2* relaxation times In this study, diffusion tensor imaging and T2* measurements were combined in seven subjects with the head in a normal and tilted position It was shown that fiber orientation has a strong influence on 12* in the human brain, with the average T2* value changing from 49 ms for a perpendicular orientation to B-0 to 57 ms for a parallel orientation to B-0 Nevertheless, T2* times showed a wide variety of values at any orientation towards B-0 Copyright (C) 2010 John Wiley & Sons, Ltd