VISUAL SENSITIVITY TO MOTION - AGE-RELATED-CHANGES AND DEFICITS IN SENILE DEMENTIA OF THE ALZHEIMER TYPE
VISUAL SENSITIVITY TO MOTION - AGE-RELATED-CHANGES AND DEFICITS IN SENILE DEMENTIA OF THE ALZHEIMER TYPE
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DOI：
10.1212/wnl.41.9.1437
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发表时间：
1991-09-01
期刊：
影响因子：
9.9
通讯作者：
SILVERMAN, SE
中科院分区：
文献类型：
--
作者：
TRICK, GL;SILVERMAN, SE
为了确定运动敏感性是否随年龄变化，我们测量了 25 至 80 岁视觉正常人的运动辨别能力，发现运动阈值随年龄线性增加，70 至 80 岁的运动阈值比 30 岁以下的参与者高出大约两倍。这种增加并非归因于瞳孔大小或视网膜图像失真，但可能反映了初级视觉通路中的神经变性。我们将阿尔茨海默型老年痴呆症 (SDAT) 患者的运动敏感性与年龄相近的正常视力子集的结果进行了比较。在 SDAT 患者中，阈值显着升高，这在痴呆症较严重的患者中更为明显。这些发现证实了先前关于视觉系统参与 SDAT 的报道，并表明运动测试可能揭示临床前视觉系统参与 SDAT。
To determine whether motion sensitivity varies with age, we measured motion discrimination in visual normals 25 to 80 years of age and found that motion thresholds increased linearly with age and were approximately two times higher in those 70 to 80 years old than in participants under thirty. This increase was not attributable to pupil size or retinal image distortion, but probably reflects neurodegeneration in the primary visual pathway. We compared the motion sensitivity of patients with senile dementia of the Alzheimer type (SDAT) with results from a subset of the visual normals of similar age. In SDAT patients, there were significant threshold elevations, which were more pronounced in the patients with more severe dementia. These findings confirm previous reports of visual system involvement in SDAT and indicate motion testing may reveal preclinical visual system involvement in SDAT.