Pure acinic cell carcinoma of the breast in an 80-year-old Japanese woman
Pure acinic cell carcinoma of the breast in an 80-year-old Japanese woman
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DOI：
10.1111/j.1440-1827.2007.02055.x
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发表时间：
2007-01-01
影响因子：
2.2
通讯作者：
Ichihara, Shu
中科院分区：
文献类型：
--
作者：
Tanahashi, Chisato;Yabuki, Suguru;Ichihara, Shu
乳腺腺泡细胞癌是一种罕见的肿瘤。自从1996年报道了第一例这种罕见的乳腺癌变异以来，英文文献中只报道了10例。本文报告日本女性乳腺腺泡细胞癌的首例病例。肉眼可见肿瘤边界清楚，切面呈灰粉色，有出血。显微镜下，肿瘤主要由单调的细胞增殖和细小的颗粒状细胞质组成，类似于腮腺的腺泡细胞。部分肿瘤细胞胞浆清晰。尽管进行了广泛的采样，但在本病例中没有发现常见的乳腺癌组织学类型，如原位癌和浸润性导管癌，这表明本病例是纯腺泡细胞癌。免疫组化结果与涎腺腺泡细胞癌一致：雌激素受体、孕激素受体、HER2和细胞角蛋白(CK)20均为阴性，淀粉酶和CK7均为阳性。自从肿瘤被广泛的局部切除后，患者已经好了22个月，到目前为止还没有明显的唾液肿瘤迹象。
Acinic cell carcinoma of the breast is an uncommon neoplasm. Since the first case of this rare variant of breast carcinoma was reported in 1996, only 10 cases have been reported in the English-language literature. Reported herein is the first case of primary acinic cell carcinoma of the breast in a Japanese woman. To the naked eye, the tumor appeared well circumscribed and the cut surface was grayish-pink and hemorrhaging. Microscopically, the tumor was predominantly made up of a monotonous proliferation of cells with a finely granular cytoplasm, resembling acinic cells of the parotid gland. Some neoplastic cells had a clear cytoplasm. In spite of extensive sampling, no common histological patterns of breast carcinoma such as in situ and invasive ductal carcinoma were recognized in the present case, indicating that the present case was pure acinic cell carcinoma. In addition, the immunohistochemical profile of this tumor was identical to that of the acinic cell carcinoma of the salivary gland: estrogen receptor, progesterone receptor, HER2 and cytokeratin (CK)20 were negative and amylase and CK7 were positive. The patient has been well for 22 months since the wide local excision of the tumor and no signs of salivary neoplasm are evident to date.