RELATIONSHIP OF BODY SIZE, NERVE CELL SIZE, AXON LENGTH, AND GLIAL DENSITY IN CEREBELLUM
RELATIONSHIP OF BODY SIZE, NERVE CELL SIZE, AXON LENGTH, AND GLIAL DENSITY IN CEREBELLUM
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DOI：
10.1073/pnas.49.2.187
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发表时间：
1963-01-01
影响因子：
11.1
通讯作者：
FRIEDE, RL
中科院分区：
文献类型：
--
作者：
FRIEDE, RL
It is generally recognized that the nerve cells of large animals are somewhat larger than the nerve cells of small animals. A quantitative comparison of cell size to body size is difficult to establish because of the variations of shape and size of nerve cells, even within one nucleus. Also, measurements of perikarya only are not an adequate determination of total cell volume because of variations in the extent of dendrite ramification.A comparative study of cell size is facilitated in the cerebellar cortex which, in its anatomical architecture and physiological function, persists remarkably constant throughout phylogenetic development. The diameter of Purkinje cells-can be measured with ease. Since all the dendrites extend toward the surface of the molecular layer, the thickness of this layer can be regarded as a parameter of maximal dendrite length. The width of the area covered by dendrite branchings can be estimated by the distance between Purkinje cells if the sections are cut in the plane of dendrite branching, that is, perpendicular to the axis of the gyri. Such measurements of nerve cells, in addition, can be compared with relative changes of glial density. The following provides a short investigation in eighteen species with the aim of indicating trends among species rather than to establish norms for each individual species.
