Pneumonitis Induced by Immune Checkpoint Inhibitors: From Clinical Data to Translational Investigation.
Pneumonitis Induced by Immune Checkpoint Inhibitors: From Clinical Data to Translational Investigation.
复制标题
免疫检查点抑制剂引起的炎症：从临床数据到转化研究。
DOI：
10.3389/fonc.2020.01785
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发表时间：
2020
影响因子：
4.7
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Zhu S;Fu Y;Zhu B;Zhang B;Wang J
免疫检查点抑制剂（ICI）已应用于临床实践，并在多种人类恶性肿瘤中取得了显著的治疗效果。这些药物不仅能增强机体的抗肿瘤免疫反应，还会产生称为免疫相关不良事件（irAE）的副作用。尽管检查点抑制剂肺炎（CIP）的临床发生率较低，但在某些严重病例中可能导致免疫治疗延迟或终止，以及治疗相关死亡。自2015年以来，CIP病例报告数量不断增加，这归因于ICI的批准和使用增加，但对CIP的全面了解仍然缺乏。本文综述了CIP的流行病学、临床特点、治疗策略和潜在机制，以加强临床医生和研究人员对CIP肺毒性的认识。
Immune checkpoint inhibitors (ICIs) have been applied to clinical practice and achieved significant therapeutic benefit in a variety of human malignancies. These drugs not only enhance the body’s antitumor immune response but also produce side effects called immune-related adverse events (irAEs). Although checkpoint inhibitor pneumonitis (CIP) has a low clinical incidence, it is likely to cause the delay or termination of immunotherapy and treatment-related death in some severe cases. An increasing number of CIP cases have been reported since 2015, which are attributed to the augmentation of approvals and uses of ICIs, but a comprehensive understanding of CIP is still lacking. This review focuses on the epidemiology, clinical characteristics, treatment strategies, and underlying mechanisms of CIP to strengthen the recognition of pulmonary toxicity among clinicians and researchers.
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DOI：
10.2169/internalmedicine.8271-16
发表时间：
2017-09-01
期刊：
Internal medicine (Tokyo, Japan)
影响因子：
--
作者：
Ishiwata T;Ebata T;Iwasawa S;Matsushima J;Ota S;Nakatani Y;Tsushima K;Tada Y;Tatsumi K;Takiguchi Y
通讯作者：
Takiguchi Y
影响因子：
10.9
作者：
Addeo, Alfredo;Obeid, Michel;Friedlaender, Alex
通讯作者：
Friedlaender, Alex
影响因子：
5.8
作者：
Franzen, Daniel;Schad, Karin;Kohler, Malcolm
通讯作者：
Kohler, Malcolm
影响因子：
3.2
作者：
Jodai, Takayuki;Yoshida, Chieko;Tomita, Yusuke
通讯作者：
Tomita, Yusuke
影响因子：
28.5
作者：
Li H;Ma W;Yoneda KY;Moore EH;Zhang Y;Pu LL;Frampton GM;Molmen M;Stephens PJ;Li T
通讯作者：
Li T