How hepatitis C virus invades hepatocytes: the mystery of viral entry.
How hepatitis C virus invades hepatocytes: the mystery of viral entry.
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DOI：
10.3748/wjg.v20.i13.3457
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发表时间：
2014-04
影响因子：
4.3
通讯作者：
Yongzhe Zhu;X. Qian;P. Zhao;Z. Qi
中科院分区：
文献类型：
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作者：
Yongzhe Zhu;X. Qian;P. Zhao;Z. Qi
丙型肝炎病毒(丙型肝炎病毒)感染是一个全球健康问题，估计有1.7亿人慢性感染。丙型肝炎病毒进入细胞是一个复杂的多步骤过程，涉及几个细胞因子，触发病毒进入肝细胞。高密度脂蛋白受体清道夫受体BI型、Tetraspanin CD81、紧密连接蛋白claudin-1和occludin是介导丙型肝炎病毒感染起始步骤的主要受体。此外，该病毒使用细胞受体酪氨酸激酶作为进入调节因子，如表皮生长因子受体和肾上腺素受体A2。本文综述了细胞表面分子如何参与丙型肝炎病毒的附着、内化和膜融合，以及宿主细胞激酶如何调控病毒进入的研究进展。介绍了针对这一过程的潜在抗病毒药物的研究进展。
Hepatitis C virus (HCV) infection is a global health problem, with an estimated 170 million people being chronically infected. HCV cell entry is a complex multi-step process, involving several cellular factors that trigger virus uptake into the hepatocytes. The high- density lipoprotein receptor scavenger receptor class B type I, tetraspanin CD81, tight junction protein claudin-1, and occludin are the main receptors that mediate the initial step of HCV infection. In addition, the virus uses cell receptor tyrosine kinases as entry regulators, such as epidermal growth factor receptor and ephrin receptor A2. This review summarizes the current understanding about how cell surface molecules are involved in HCV attachment, internalization, and membrane fusion, and how host cell kinases regulate virus entry. The advances of the potential antiviral agents targeting this process are introduced.